Cytokine response in crimean-congo hemorrhagic fever virus infection

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dc.authorid0000-0003-1935-9235
dc.authorid0000-0002-2398-8686
dc.contributor.authorErgönül, Önder
dc.contributor.authorŞeref, Ceren
dc.contributor.authorEren, Şebnem
dc.contributor.authorÇelikbaş, Aysel
dc.contributor.authorBaykam, Nurcan
dc.contributor.authorDokuzoğuz, Başak
dc.contributor.authorGönen, Mehmet
dc.contributor.authorCan, Füsun
dc.date.accessioned2019-05-10T09:39:32Z
dc.date.available2019-05-10T09:39:32Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractWe described the predictive role of cytokines in fatality of Crimean Congo Hemorrhagic Fever Virus (CCHFV) infection by using daily clinical sera samples. Consequent serum samples of the selected patients in different severity groups and healthy controls were examined by using human cytokine 17-plex assay. We included 12 (23%) mild, 30 (58%) moderate, 10 (19%) severe patients, and 10 healthy volunteers. The mean age of the patients was 52 (sd 15), 52% were female. Forty-six patients (88%) received ribavirin. During disease course, the median levels of IL-6, IL-8, IL-10, IL-10/12, IFN-?, MCP-1, and MIP-1b were found to be significantly higher among CCHF patients than the healthy controls. Within the first 5 days after onset of disease, among the fatal cases, the median levels of IL-6 and IL-8 were found to be significantly higher than the survived ones (Fig. 3), and MCP-1 was elevated among fatal cases, but statistical significance was not detected. In receiver operating characteristic (ROC) analysis, IL-8 (92%), IL-6 (92%), MCP-1 (79%) were found to be the most significant cytokines in predicting the fatality rates in the early period of the disease (5 days). IL-6 and IL-8 can predict the poor outcome, within the first 5 days of disease course. Elevated IL-6 and IL-8 levels within first 5 days could be used as prognostic markers. © 2017 Wiley Periodicals, Inc.
dc.identifier.citationErgönül, Ö., Şeref, C., Eren, Ş., Çelikbaş, A., Baykam, N., Dokuzoğuz, B., ... & Can, F. (2017). Cytokine response in crimean?congo hemorrhagic fever virus infection. Journal of medical virology, 89(10), 1707-1713.
dc.identifier.doi10.1002/jmv.24864
dc.identifier.endpage1713en_US
dc.identifier.issn0146-6615
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1707en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.24864
dc.identifier.urihttps://hdl.handle.net/11491/723
dc.identifier.volume89en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.relation.ispartofJournal of Medical Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCrimean-Congo Hemorrhagic Feveren_US
dc.subjectCytokineen_US
dc.subjectRibavirinen_US
dc.titleCytokine response in crimean-congo hemorrhagic fever virus infection
dc.typeArticle

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