Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?

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dc.contributor.authorKekilli, Murat
dc.contributor.authorTanoğlu, Alpaslan
dc.contributor.authorSakin, Yusuf Serdar
dc.contributor.authorKurt, Mevlüt
dc.contributor.authorÖcal, Serkan
dc.contributor.authorBağcı, Sait
dc.date.accessioned2019-05-13T08:58:37Z
dc.date.available2019-05-13T08:58:37Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractAIM: To determine the association between the neutrophil to lymphocyte (N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B (CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the "no/minimal liver fibrosis" group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the "advanced liver fibrosis" group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically significant. RESULTS: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the "no/minimal fibrosis" group included 79 individuals, while the "advanced fibrosis" group included 50 individuals. Mean (N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal fibrosis. CONCLUSION: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB. © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
dc.identifier.citationKekilli, M., Tanoğlu, A., Sakin, Y. S., Kurt, M., Öcal, S., Bağcı S. (2015). Is theneutrophil to lymphocyte ratio associated with liver fibrosis inpatients with chronic hepatitis B? World Journal of Gastroenterology, 21(18), 5575-5581.
dc.identifier.doi10.3748/wjg.v21.i18.5575
dc.identifier.endpage5581en_US
dc.identifier.issn1007-9327
dc.identifier.issue18en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage5575en_US
dc.identifier.urihttps://doi.org/10.3748/wjg.v21.i18.5575
dc.identifier.urihttps://hdl.handle.net/11491/1169
dc.identifier.volume21en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBaishideng Publishing Group Inc.
dc.relation.ispartofWorld Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic Hepatitis Ben_US
dc.subjectFibrotic Stageen_US
dc.subjectInflammatory Activityen_US
dc.subjectLiver Fibrosisen_US
dc.subjectNeutrophil to Lymphocyte Ratioen_US
dc.subjectNon-Invasive Markeren_US
dc.titleIs the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?
dc.typeArticle

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