Clinical and pathological significance of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer

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dc.authoridKoçak, Cem / 0000-0002-7339-7438
dc.authoridKeser Şahin, Havva Hande / 0000-0003-1827-1039
dc.authoridHelvacı, Kaan / 0000-0002-8394-8168
dc.authoridAkdeniz, Raşit / 0000-0003-2249-0816
dc.authoridBaş, Yılmaz / 0000-0002-4229-8568
dc.authorwosidKoçak, Cem / AAP-6074-2021
dc.authorwosidHelvacı, Kaan / Y-8595-2018
dc.contributor.authorBaş, Yılmaz
dc.contributor.authorKoç, Nermin
dc.contributor.authorHelvacı, Kaan
dc.contributor.authorKoçak, Cem
dc.contributor.authorAkdeniz, Raşit
dc.contributor.authorKeser Şahin, Havva Hande
dc.date.accessioned2021-11-01T15:05:44Z
dc.date.available2021-11-01T15:05:44Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractWe investigated programmed cell death 1 (PD-1) / programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer (HGSOC) and its relationship to tumor infiltrating lymphocytes (TIL) and prognosis. Formalin fixed paraffin embedded (FFPE) samples of 94 HGSOC cases were included in the study. Immunohistochemical analysis (CD3, CD4, CD8, PD-1 and PD-L1) was performed. Samples were analyzed for expression of immune proteins in the peritumoral stromal and intratumoral areas, scored, and expression was correlated with overall survival, stage, and age. PD-L1 staining ratio with a score greater than 0 was found to have lower survival. There were two positive staining patterns, patchy/diffuse and patchy/focal patterns, in 24 (25.5%) cases. Considering the threshold value >= 5%, we demonstrated that the PD-L1 positive cancer cell membrane immunoreactivity rate and patchy/diffuse PD-L1 expression were 9.6% (n = 9). There was statistically significant relationship between high PD-1 scores and PD-L1 cases of >= 5%. A statistically significant difference was found between PD-L1 staining and survival in patients with a threshold >= 5%. However an appropriate rate for treatment was determined in 9.6% cases. There was a statistically significant correlation between PD-1 positive TIL score and intratumoral CD3, peritumoral stromal CD3, intratumoral CD4 and intratumoral CD8 positive cells. Survival was lower in cases with higher PD-L1 positive stromal TIL score.
dc.identifier.citationBaş, Y., Koç, N., Helvacı, K., Koçak, C., Akdeniz, R., & Şahin, H. H. K. (2021). Clinical and pathological significance of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer. Translational Oncology, 14(2), 100994.
dc.identifier.doi10.1016/j.tranon.2020.100994
dc.identifier.issn1936-5233
dc.identifier.issue2en_US
dc.identifier.pmid33333370
dc.identifier.scopus2-s2.0-85097765204
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.tranon.2020.100994
dc.identifier.urihttps://hdl.handle.net/11491/7387
dc.identifier.volume14en_US
dc.identifier.wosWOS:000615945000006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKoçak, Cem
dc.institutionauthorHelvacı, Kaan
dc.institutionauthorBaş, Yılmaz
dc.institutionauthorAkdeniz, Raşit
dc.institutionauthorKeser Şahin, Havva Hande
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofTranslational Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHigh Grade Serous Ovarian Canceren_US
dc.subjectProgrammed Cell Death 1en_US
dc.subjectProgrammed Cell Death Ligand 1en_US
dc.subjectTumor Infiltrating Lymphocytesen_US
dc.subjectSurvivalen_US
dc.titleClinical and pathological significance of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer
dc.typeArticle

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