Association between Alzheimer’s disease, MAPT genemutation and some biochemical biomarkers

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dc.contributor.authorŞen, Ayşenur
dc.contributor.authorAvşar, Orçun
dc.contributor.authorEliaçık, Sinan
dc.contributor.authorUysal Tan, Funda
dc.date.accessioned2024-08-02T07:38:01Z
dc.date.available2024-08-02T07:38:01Z
dc.date.issued2024en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractAlzheimer’s Disease (AD) is a multifactorial neurodegenerativedisease and there is still no definitive treatment today. Earlydiagnosis of the disease is important, but there are almost nobiomarkers that can be used in early diagnosis. The cerebro-spinal fluid used in the diagnosis of the disease is not suffi-cient and is very difficult to obtain. Therefore, blood biomarkersthat are less costly, less invasive, easily accessible, and can beused in long-term studies would be a better alternative. Theaim of this study is to determine the relationship betweenAlzheimer’s Disease and P301L MAPT gene mutation, homo-cysteine, folate and uric acid. 101 Alzheimer’s patients and101 healthy individuals were included in this study. Mutationanalysis was performed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) methodwith blood samples taken from the subjects. There was nosignificant difference between the patient and control groupsin terms of homocysteine (p = 0.771), folate (p = 0.366) and uricacid (p = 0.860). When the genotypes were compared betweenthe patient and control groups in terms of MAPT gene muta-tion (P301L), no statistically significant difference was detected(p = 0.081). There are very few studies in the literature investi-gating the relationship between Alzheimer’s disease and P301LMAPT gene mutation. Additionally, there is no study investigat-ing the relationship between Alzheimer’s disease and homocys-teine, folate, uric acid and P301L MAPT mutation in the Turkishpopulation. We believe that this study has shed light on futurestudies.
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dc.identifier.citationSen, A., Avsar, O., Eliacik, S., & Uysal Tan, F. (2024). Association between Alzheimer’s disease, MAPT gene mutation and some biochemical biomarkers. Nucleosides, Nucleotides & Nucleic Acids, 1-10.
dc.identifier.doi10.1080/15257770.2024.2313573
dc.identifier.issn1525-7770
dc.identifier.issn1532-2335
dc.identifier.pmid38319996
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1080/15257770.2024.2313573
dc.identifier.urihttps://hdl.handle.net/11491/9048
dc.identifier.wosWOS:001158389000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞen, Ayşenur
dc.institutionauthorAvşar, Orçun
dc.institutionauthorEliaçık, Sinan
dc.institutionauthorUysal Tan, Funda
dc.language.isoen
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlzheimer’s diseaseen_US
dc.subjectMAPTen_US
dc.subjectMutationen_US
dc.subjectBiomarkersen_US
dc.titleAssociation between Alzheimer’s disease, MAPT genemutation and some biochemical biomarkers
dc.typeArticle

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