Expressions of glutathione S-transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea

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dc.authoridKılıç, Murat / 0000-0002-1377-2021
dc.authoridTakcı, Zennure / 0000-0001-7257-5792
dc.authorwosidKılıç, Murat / V-4843-2017
dc.contributor.authorTakcı, Zennure
dc.contributor.authorGüneş Bilgili, Serap
dc.contributor.authorKılıç, Murat
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorMoran Bozer, Büşra
dc.contributor.authorŞimşek, Gülçin Güler
dc.contributor.authorKaradağ, Ayşe Serap
dc.date.accessioned2021-11-01T15:05:18Z
dc.date.available2021-11-01T15:05:18Z
dc.date.issued2020
dc.departmentRektörlük
dc.description.abstractBackground Data point to the importance of oxidative stress in rosacea. Glutathione S-transferases (GSTs) have substantial roles in a wide variety of oxidative stress-related conditions. Aim To evaluate the immunohistochemical staining characteristics of GST alpha (GSTA), mu (GSTM), pi (GSTP), and theta (GSTT) in patients with rosacea. Patients/Methods The study included 23 women and 7 men with rosacea (mean +/- SD age 49 +/- 11 year) and 15 healthy control subjects (10 women, 5 men; mean +/- SD age 47.86 +/- 10.88 year). For each patient, the average disease duration, disease subtype, ocular involvement, and severity score were recorded. A 3-mm punch biopsy was taken from the facial skin of each patient and control. Expression of GST isoenzymes was analyzed immunohistochemically. Results Expressions of GSTM1, GSTP1, and GSTT1 were significantly elevated in patients with rosacea compared to those in the control group (P = .0001,P = .0002,P < .0001, respectively). In the rosacea group, GSTT1 expression was significantly stronger than GSTP1 and GSTA1 expressions (P = .019,P < .0001, respectively). There were no significant associations between expressions of GST isoenzymes and gender, age, average duration of illness, disease subtype, ocular involvement, or severity score in the patient group (allP > .05). Conclusions In rosacea, the significant increase of GSTT1, GSTP1, and GSTM1 expressions might result from activation of GST as an outcome of extreme free radical generation from triggered neutrophils or ultraviolet vulnerability. These findings support the relevance of oxidant stress in the pathogenesis of rosacea.
dc.description.sponsorshipYuzuncu Yil University Scientific ProjectYuzuncu Yil University [2012-TF-B014]en_US
dc.description.sponsorshipThis work was supported by Yuzuncu Yil University Scientific Project (2012-TF-B014).en_US
dc.identifier.citationTakci, Z., Gunes Bilgili, S., Kilic, M., Oguztuzun, S., Bozer, B., Guler Simsek, G., ... & Karadag, A. S. (2020). Expressions of glutathione S?transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea. Journal of Cosmetic Dermatology, 19(8), 2070-2075.
dc.identifier.doi10.1111/jocd.13501
dc.identifier.endpage2075en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue8en_US
dc.identifier.pmid32433803
dc.identifier.scopus2-s2.0-85086276773
dc.identifier.scopusqualityQ2
dc.identifier.startpage2070en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.13501
dc.identifier.urihttps://hdl.handle.net/11491/7219
dc.identifier.volume19en_US
dc.identifier.wosWOS:000539720000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMoran Bozer, Büşra
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal Of Cosmetic Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGlutathione S-transferaseen_US
dc.subjectImmunohistochemistryen_US
dc.subjectRosaceaen_US
dc.titleExpressions of glutathione S-transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea
dc.typeArticle

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