The predictive value of CHADS2 score for subclinical cerebral ischemia after carotid artery stenting (from the PREVENT-CAS trial)

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dc.contributor.authorÇelik, Ömer
dc.contributor.authorGüner, Ahmet
dc.contributor.authorKalçık, Macit
dc.contributor.authorGüler, Arda
dc.contributor.authorDemir, Ali Riza
dc.contributor.authorDemir, Yusuf
dc.contributor.authorErtürk, Mehmet
dc.date.accessioned2021-11-01T15:05:43Z
dc.date.available2021-11-01T15:05:43Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractAbstarct Background Carotid artery stenting (CAS) is being increasingly used as an alternative revascularization procedure to carotid endarterectomy; however, subclinical ischemic cerebral lesions after CAS remain as a matter of concern. Hence, we aimed to assess the clinical utility of the CHADS(2) score in predicting subclinical ischemic events after CAS. Methods We prospectively evaluated 107 patients (mean age: 70.4 +/- 6.6 years, male:77) who underwent CAS for carotid artery revascularization. The patients having symptomatic transient ischemic attack or stroke after CAS were excluded. The presence of new hyperintense lesion on diffusion-weighted imaging (DWI) without any neurological findings was considered as silent ischemia. Patients were classified into two groups as DWI-positive and DWI-negative patients. Results Among study population, 28 patients (26.2%) had subclinical embolism. The DWI-positive group had a significantly higher CHADS2 scores, older age, more frequent history of stroke, higher proportion of type III aortic arch, and longer fluoroscopy time than the DWI-negative group. Increased CHADS(2) score was identified as one of the independent predictors of silent embolism (OR = 5.584; 95%CI: 1.516-20.566; p = .010), and CHADS(2) score higher than 2.5 predicted subclinical cerebral ischemia with a sensitivity of 72% and a specificity of 71% (AUC: 0.793; 95% CI: 0.696 - 0.890; p < .001). Conclusions CHADS(2) score was able to predict the risk of periprocedural subclinical ischemic events in CAS and might be of clinical value in the management of patients with carotid artery stenosis.
dc.identifier.citationÇelik, Ö., Güner, A., Kalçık, M., Güler, A., Demir, A. R., Demir, Y., ... & Ertürk, M. (2021). The predictive value of CHADS2 score for subclinical cerebral ischemia after carotid artery stenting (from the PREVENT?CAS trial). Catheterization and Cardiovascular Interventions, 97(2), 301-309.
dc.identifier.doi10.1002/ccd.29344
dc.identifier.endpage309en_US
dc.identifier.issn1522-1946
dc.identifier.issn1522-726X
dc.identifier.issue2en_US
dc.identifier.pmid33085162
dc.identifier.scopus2-s2.0-85092394834
dc.identifier.scopusqualityQ1
dc.identifier.startpage301en_US
dc.identifier.urihttps://doi.org/10.1002/ccd.29344
dc.identifier.urihttps://hdl.handle.net/11491/7380
dc.identifier.volume97en_US
dc.identifier.wosWOS:000581116800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKalçık, Macit
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofCatheterization And Cardiovascular Interventions
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarotiden_US
dc.subjectCarotid Artery Diseaseen_US
dc.subjectImagingen_US
dc.subjectInterventionen_US
dc.subjectInterventional MRIen_US
dc.subjectStrokeen_US
dc.subjectSurgeryen_US
dc.titleThe predictive value of CHADS2 score for subclinical cerebral ischemia after carotid artery stenting (from the PREVENT-CAS trial)
dc.typeArticle

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