Relationship between intracoronary thrombus burden and systemic immune-inflammation index in patients with ST-segment elevation myocardial infarction

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dc.authorid0000-0003-0033-4353
dc.authorid0000-0002-8791-4475
dc.authorid0000-0002-6496-7849
dc.authorid0000-0002-1142-5974
dc.authorid0000-0001-6255-711X
dc.authorwosidHPD-5255-2023
dc.authorwosidHOC-0196-2023
dc.contributor.authorDolu, Abdullah Kadir
dc.contributor.authorKarayiğit, Orhan
dc.contributor.authorÖzkan, Can
dc.contributor.authorÇelik, Muhammet Cihat
dc.contributor.authorKalçık, Macit
dc.date.accessioned2024-01-25T12:15:55Z
dc.date.available2024-01-25T12:15:55Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractAim:This study aimed to evaluate the relationship between intracoronary thrombus burdenand systemic immune-inflammation index (SII) and to compare the predictive capacity of SIItogether with the neutrophil-lymphocyte ratio (NLR), and the platelet-lymphocyte ratio (PLR) inpatients with ST-elevation myocardial infarction (STEMI) who underwent primary percutaneouscoronary intervention (PPCI)Patient & methods:A total of 425 patients were included in the study. The clinical, laboratory,and demographic characteristics of the patients were recorded. The thrombus classification"Thrombolysis in myocardial infarction (TIMI)" was used to assess the intracoronary thrombusburden. According to the TIMI thrombus classification, 229 (54%) patients with low thrombusburden (grade 0–3) and 196 (46%) patients with high thrombus burden (grade 4 and 5) werecompared. SII was calculated as platelet neutrophil/lymphocyte counts.Results:High NLR (OR: 1.068, 95% CI:1.023–1.404;p¼0.031), PLR(OR: 1.012, 95% CI:1.002–1.018;p¼0.043), SII(OR: 1.325, 95% CI: 1.156–1.879;p¼0.015) and low left ventricle ejection fraction(LVEF) (OR: 0.957, 95% CI:0.924–0.990;p¼0.012) were found to be independent predictors ofhigh thrombus burden. SII values above 812 predicted a high thrombus burden with a sensitiv-ity of 82% and specificity of 73% (AUC: 0.836; 95% CI:0.795–0.877;p<0.001). This predictivenessof SII was stronger as compared to NLR (0.836 vs. 0.818,p¼0.043) and PLR (0.836 vs.0.780,p<0.001).Conclusion:SII is an independent predictor of high thrombus burden in patients with STEMI. Inaddition, SII is superior to NLR and PLR in this regard.
dc.description.provenanceSubmitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-01-25T12:15:44Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-01-25T12:15:55Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2024-01-25T12:15:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2023en
dc.identifier.citationDolu, A. K., Karayiğit, O., Ozkan, C., Çelik, M. C., & Kalçık, M. (2023). Relationship between intracoronary thrombus burden and systemic immune-inflammation index in patients with ST-segment elevation myocardial infarction. Acta Cardiologica, 78(1), 72-79.
dc.identifier.doi10.1080/00015385.2022.2035082
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.pmid35105281
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1080/00015385.2022.2035082
dc.identifier.urihttps://hdl.handle.net/11491/8743
dc.identifier.wosWOS:000750226800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelik, Muhammet Cihat
dc.institutionauthorKalçık, Macit
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofACTA CARDIOLOGICA
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInflammationen_US
dc.subjectST-segmentelevation myocardialinfarctionen_US
dc.subjectSystemicimmune-inflammationindexen_US
dc.subjectThrombus burdenen_US
dc.subjectNeutrophil-lymphocyte ratioen_US
dc.subjectPlatelet-lymphocyte ratioen_US
dc.titleRelationship between intracoronary thrombus burden and systemic immune-inflammation index in patients with ST-segment elevation myocardial infarction
dc.typeArticle

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