Geographical Variations in Patients with Heart Failure and Preserved Ejection Fraction: A Sub-Group Analysis of the APOLLON Registry

Basit Öğe Kaydı
dc.contributor.authorÖzlek, Bülent
dc.contributor.authorÖzlek, Eda
dc.contributor.authorAguş, Hicaz Zencirkıran
dc.contributor.authorTekinalp, Mehmet
dc.contributor.authorKahraman, Serkan
dc.contributor.authorÇelik, Oğuzhan
dc.contributor.authorBiteker, Murat
dc.date.accessioned2021-11-01T18:14:55Z
dc.date.available2021-11-01T18:14:55Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractBackground: Clinical characteristics of patients with heart failure may vary geographically. However, limited data are available regarding the geographical differences of patients with heart failure and preserved ejection fraction. Aims: The present subgroup analysis aims to investigate the geographical differences in clinical characteristics, management, and primary etiology of patients with heart failure and preserved ejection fraction in Turkey. Study Design: A cross-sectional study. Methods: A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejection fractiON (APOLLON) is a multicenter and observational study conducted in seven regions of Turkey (NCT03026114). The present study is a post-hoc analysis of the APOLLON registry. In this substudy, we compared the clinical characteristics of 819 consecutive patients with heart failure and preserved ejection fraction (mean age, 67 years; 57.8% women) admitted to cardiology outpatient units in different geographical regions. Results: Based on the geographical distribution of the entire Turkish population, the highest number of patients enrolled were from Marmara (271 patients, 33.1%). All demographical characteristics, clinical and laboratory findings, comorbidities, primary etiology, and medications prescribed were significantly different between the regions. Furthermore, inter-regional gender differences were identified. Comparatively, the Aegean and Mediterranean regions had older patients with heart failure and preserved ejection fraction (p<0.001), and the Black Sea, Southeast, and East Anatolia regions had predominantly male patients (51.2, 54.5, and 56.9%, respectively; p=0.002). Notably, the Mediterranean and Southeast Anatolia had more symptomatic patients, and history of hospitalization for heart failure was more prevalent in Southeast Anatolia (33.3%, p<0.001). Prevalence of atrial fibrillation was higher in the Mediterranean and Southeast Anatolia regions (51 and 48.5%, p<0.001), and patients with heart failure and preserved ejection fraction had a higher prevalence of hypertension in the Mediterranean, Southeast Anatolia, and Black Sea regions (p=0.002). Angiotensin-converting enzyme inhibitors were more frequently prescribed in East Anatolia (52.3%, p=0.001), and the prevalence of patients with heart failure and preserved ejection fraction using loop diuretics (48.8%, p=0.003) was higher in the Black Sea region. Conclusion: This study was the first to show geographical differences in clinical characteristics of patients with heart failure and preserved ejection fraction in Turkey. Determination of the clinical characteristics of the heart failure and preserved ejection fraction population based on the geographical region may enables physicians to adopt a region-specific clinical approach toward heart failure and preserved ejection fraction.
dc.identifier.doi10.4274/balkanmedj.galenos.2019.2019.2.17
dc.identifier.endpage244en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.pmid30945522
dc.identifier.scopus2-s2.0-85069623334
dc.identifier.scopusqualityQ1
dc.identifier.startpage235en_US
dc.identifier.urihttps://doi.org10.4274/balkanmedj.galenos.2019.2019.2.17
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpFNU1UZzNOdz09
dc.identifier.urihttps://hdl.handle.net/11491/7586
dc.identifier.volume36en_US
dc.identifier.wosWOS:000474449600008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.relation.ispartofBalkan Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKlinik Nörolojien_US
dc.subjectSağlık Bilimleri ve Hizmetlerien_US
dc.subjectTıbbi İnformatiken_US
dc.subjectGenel ve Dahili Tıpen_US
dc.subjectTıbbi Araştırmalar Deneyselen_US
dc.subjectTemel Sağlık Hizmetlerien_US
dc.subjectCerrahien_US
dc.titleGeographical Variations in Patients with Heart Failure and Preserved Ejection Fraction: A Sub-Group Analysis of the APOLLON Registry
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu