The efficacy of mesenchymal stem cell transplantation in caustic esophagus injury: an experimental study

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dc.contributor.authorKantarcıoğlu, Murat
dc.contributor.authorÇalışkan, Bahadır
dc.contributor.authorDemirci, Hakan
dc.contributor.authorKaracalioğlu, Özgür
dc.contributor.authorKekilli, Murat
dc.contributor.authorPolat, Zülfikar
dc.contributor.authorGünal, Armağan
dc.contributor.authorAkıncı, Melih
dc.contributor.authorUysal, Çağrı
dc.contributor.authorEksert, Sami
dc.contributor.authorGürel, Hasan
dc.contributor.authorÇelebi, Gürkan
dc.contributor.authorAvcu, Ferit
dc.contributor.authorUral, Ali Uğur
dc.contributor.authorBağcı, Sait
dc.date.accessioned2019-05-13T09:07:00Z
dc.date.available2019-05-13T09:07:00Z
dc.date.issued2014
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractIntroduction. Ingestion of corrosive substances may lead to stricture formation in esophagus as a late complication. Full thickness injury seems to exterminate tissue stem cells of esophagus. Mesenchymal stem cells (MSCs) can differentiate into specific cell lineages and have the capacity of homing in sites of injury. Aim and Methods. We aimed to investigate the efficacy of MSC transplantation, on prevention of esophageal damage and stricture formation after caustic esophagus injury in rats. 54 rats were allocated into four groups; 4 rats were sacrificed for MSC production. Group 1, untreated controls (n: 10). Group 2, membrane labeled MSCs-treated rats (n: 20). Group 3, biodistribution of fluorodeoxyglucose labeled MSCs via positron emission tomography (PET) imaging (n: 10). Group 4, sham operated (n: 10). Standard caustic esophageal burns were created and MSCs were transplanted 24 hours after. All rats were sacrificed at the 21st days. Results. PET scan images revealed the homing behavior of MSCs to the injury site. The histopathology damage score was not significantly different from controls. However, we demonstrated Dil labeled epithelial and muscle cells which were originating from transplanted MSCs. Conclusion. MSC transplantation after caustic esophageal injury may be a helpful treatment modality; however, probably repeated infusions are needed. © 2014 Murat Kantarcioglu et al.
dc.identifier.citationKantarcioğlu, M., Çalışkan, B., Demirci, H., Karacalioğlu, O., Kekilli, M., Polat, Z., Günal, A., Akıncı, M. [et al.].(2014). The efficacy of mesenchymal stem cell transplantation in caustic esophagus injury: an experimental study. Stem Cells International, 2014.
dc.identifier.doi10.1155/2014/939674
dc.identifier.issn1687-9678
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/2014/939674
dc.identifier.urihttps://hdl.handle.net/11491/1699
dc.identifier.volume2014en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE Publications Inc.
dc.relation.ispartofStem Cells International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 3.0 Unported (CC BY 3.0)*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/*
dc.subject[Belirlenecek]en_US
dc.titleThe efficacy of mesenchymal stem cell transplantation in caustic esophagus injury: an experimental study
dc.typeArticle

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