Investigation of ICAM-1 levels in hypertensive patients with fragmented QRS complexes

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dc.contributor.authorBekar, Lütfü
dc.contributor.authorKalçık, Macit
dc.contributor.authorKatar, Muzaffer
dc.contributor.authorYetim, Mücahit
dc.contributor.authorÇelik, Oğuzhan
dc.contributor.authorDoğan, Tolga
dc.contributor.authorKaravelioğlu, Yusuf
dc.contributor.authorGölbaşı, Zehra
dc.date.accessioned2019-05-10T09:38:46Z
dc.date.available2019-05-10T09:38:46Z
dc.date.issued2019
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjective: Fragmented QRS (fQRS) detected on a 12-lead electrocardiogram (ECG) has been demonstrated to be a marker of myocardial fibrosis. Intercellular adhesion molecule-1 (ICAM-1) is a protein which plays an important role in fibro-inflammatory processes. In this study, we aimed to investigate the relationship between ICAM-1 levels and the presence of fQRS in hypertensive patients. Methods: Ninety consecutive patients who were diagnosed with hypertension were included in the study. ECG and transthoracic echocardiography were performed to all patients. fQRS was defined as additional R’ wave or notching/splitting of S wave in two contiguous ECG leads. Serum ICAM-1 levels were measured using the enzyme-linked immunosorbent assay method. Patients were divided into two groups according to the presence of fQRS. Results: A total of 90 patients (female, 65%; mean age: 54.6 ± 8.5 years) were included in the study. fQRS was detected on ECG recordings of 47 (52.2%) patients. The demographic characteristics were similar between the groups. Left atrial diameter (p =.003), interventricular septal thickness (p =.013), posterior wall thickness (p =.01), left ventricular mass (p =.002), left ventricular mass index (p <.001), left ventricular hypertrophy (p =.001), and ICAM-1 levels (p <.001) were found to be significantly increased in fQRS(+) group. In multivariate analysis, only high ICAM-1 level was observed to be an independent predictor for the presence of fQRS (odds ratio: 1.029; 95%Confidence Interval: 1.013–1.045, p <.001). Conclusion: A significant association exists between serum ICAM-1 levels and the presence of fQRS in hypertensive patients. The presence of fQRS may be used as an indicator of inflammation in hypertensive patients. © 2019, © 2019 Belgian Society of Cardiology.
dc.identifier.citationBekar, L., Kalçık, M., Katar, M., Yetim, M., Çelik, O., Doğan, T., Karavelioğlu, Y., Gölbaşı, Z. (2019). Investigation of ICAM-1 levels in hypertensive patients with fragmented QRS complexes. Acta cardiologica, 1-7 .
dc.identifier.doi10.1080/00015385.2018.1555200
dc.identifier.issn0001-5385
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1080/00015385.2018.1555200
dc.identifier.urihttps://hdl.handle.net/11491/458
dc.identifier.wosWOS:000518500300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofActa Cardiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEchocardiographyen_US
dc.subjectFragmented QRS Complexen_US
dc.subjectHypertensionen_US
dc.subjectInflammationen_US
dc.subjectIntercellular Adhesion Moleculeen_US
dc.subjectMyocardial Fibrosisen_US
dc.titleInvestigation of ICAM-1 levels in hypertensive patients with fragmented QRS complexes
dc.typeArticle

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