Evaluation of nasal mucociliary clearance time in children with celiac disease

Basit Öğe Kaydı
dc.authoridComba, Atakan / 0000-0002-8576-9550
dc.authorwosidAtan, Doğan / AAZ-2757-2021
dc.contributor.authorComba, Atakan
dc.contributor.authorAtan, Doğan
dc.date.accessioned2021-11-01T15:03:08Z
dc.date.available2021-11-01T15:03:08Z
dc.date.issued2020
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjectives: Celiac disease is an autoimmune disorder that develops because of sensitivity to gluten-containing grains in genetically disposed individuals. Nasal mucociliary clearance is the most important protective factor that protects the upper and lower airways from foreign particulates. This study aimed to investigate the effect of celiac disease on nasal mucociliary clearance. Methods: The study included patients with celiac disease and healthy children. Nasal mucociliary clearance time was measured using the saccharin test. The children's saccharin taste time was recorded in seconds. Results: Overall, 65 children were included: 43 patients with celiac disease (66.2%) and 22 healthy children (33.8%). Of all the children, 42 (64.6%) were female, and the average age was 11.8 +/- 4 years. Nasal mucociliary clearance time of patients with celiac disease (531 +/- 155 s) was significantly prolonged in comparison to that of healthy children (448 +/- 80 s) (p = 0.006). No relationships were found between the diagnosis age, celiac type, and histopathological phase and compliance with the gluten-free diet and nasal mucociliary clearance time of patients with celiac disease. Conclusions: This study showed that nasal mucociliary clearance was prolonged in patients with celiac disease. A defect in nasal mucociliary clearance increases the risk of infection and inflammation in small airways. Studies reported a high prevalence of respiratory tract infection in patients with celiac disease, which was associated with malnutrition, vitamin deficiency, and hyposplenism. The findings of the present study indicated that impairment of nasal mucociliary clearance could play a role in the development of frequent lung infections in patients with celiac disease.
dc.identifier.citationComba, A., & Atan, D. (2020). Evaluation of nasal mucociliary clearance time in children with celiac disease. International journal of pediatric otorhinolaryngology, 133, 109936.
dc.identifier.doi10.1016/j.ijporl.2020.109936
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.pmid32088546
dc.identifier.scopus2-s2.0-85079645409
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2020.109936
dc.identifier.urihttps://hdl.handle.net/11491/6985
dc.identifier.volume133en_US
dc.identifier.wosWOS:000531533600019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorComba, Atakan
dc.institutionauthorAtan, Doğan
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCeliac Diseaseen_US
dc.subjectChilden_US
dc.subjectNasal Mucociliary Clearanceen_US
dc.subjectRespiratory Systemen_US
dc.subjectInfectionen_US
dc.titleEvaluation of nasal mucociliary clearance time in children with celiac disease
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu