Thiolated Cellulose: A Dual-Acting Mucoadhesive and Permeation-Enhancing Polymer

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dc.authorid0000-0003-1535-4381
dc.authorid0000-0003-4187-8277
dc.authorid0000-0002-8538-6971
dc.authorwosidAFD-5344-2022
dc.authorwosidD-5833-2011
dc.contributor.authorKali, Gergely
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorLaffleur, Flavia
dc.contributor.authorKnoll, Patrick
dc.contributor.authorWibel, Richard
dc.contributor.authorZoller, Katrin
dc.contributor.authorBernkop-Schnurch, Andreas
dc.date.accessioned2023-11-28T07:56:57Z
dc.date.available2023-11-28T07:56:57Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Mühendisliği Bölümü
dc.description.abstractThis study aims to design an anionic, thiolated cellulose derivative and to evaluate its mucoadhesive and permeation-enhancing properties utilizing enoxaparin as a model drug. 2-Mercaptosuccinic acid-modified cellulose (cellulose–mercaptosuccinate) was synthesized by the reaction of cellulose with S-acetylmercaptosuccinic anhydride. The chemical structure of the target compound was confirmed by FTIR and 1H NMR spectroscopy. The thiol content was determined by Ellman’s test. The conjugate exhibited 215.5 ± 25 ?mol/g of thiol groups and 84 ± 16 ?mol/g of disulfide bonds. Because of thiolation, mucoadhesion on porcine intestinal mucosa was 9.6-fold enhanced. The apparent permeability (Papp) of the model dye Lucifer yellow was up to 2.2-fold improved by 0.5% cellulose–mercaptosuccinate on a Caco-2 cell monolayer. Enoxaparin permeation through rat intestinal mucosa increased 2.4-fold in the presence of 0.5% cellulose–mercaptosuccinate compared with the drug in buffer only. In vivo studies in rats showed an oral bioavailability of 8.98% using cellulose–mercaptosuccinate, which was 12.5-fold higher than that of the aqueous solution of the drug. Results of this study show that the modification of cellulose with 2-mercaptosuccinic acid provides mucoadhesive and permeation-enhancing properties, making this thiolated polymer an attractive excipient for oral drug delivery.
dc.description.provenanceSubmitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2023-11-28T07:55:52Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2023-11-28T07:56:57Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2023-11-28T07:56:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2023en
dc.identifier.citationKali, G., O?zkahraman, B., Laffleur, F., Knoll, P., Wibel, R., Zo?ller, K., & Bernkop-Schnu?rch, A. (2023). Thiolated Cellulose: A Dual-Acting Mucoadhesive and Permeation-Enhancing Polymer. Biomacromolecules, 24(11), 4880-4889.
dc.identifier.doi10.1021/acs.biomac.3c00577
dc.identifier.endpage4889en_US
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.issue11en_US
dc.identifier.pmid37796043
dc.identifier.scopusqualityQ1
dc.identifier.startpage4880en_US
dc.identifier.urihttps://doi.org/10.1021/acs.biomac.3c00577
dc.identifier.urihttps://hdl.handle.net/11491/8714
dc.identifier.volume24en_US
dc.identifier.wosWOS:001082118000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkahraman, Bengi
dc.language.isoen
dc.publisherAMER CHEMICAL SOC
dc.relation.ispartofBIOMACROMOLECULES
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCellsen_US
dc.subjectCelluloseen_US
dc.subjectDyes and pigmentsen_US
dc.subjectInterface engineeringen_US
dc.subjectThiolsen_US
dc.titleThiolated Cellulose: A Dual-Acting Mucoadhesive and Permeation-Enhancing Polymer
dc.typeArticle

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