Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure

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dc.authorid0000-0003-1046-8208
dc.contributor.authorAvcı, Emre
dc.contributor.authorÇakır, Erdinç
dc.contributor.authorCoşkun Cevher, Şule
dc.contributor.authorYaman, Halil
dc.contributor.authorAğıllı, Mehmet
dc.contributor.authorBilgi, Cumhur
dc.date.accessioned2019-05-13T09:08:14Z
dc.date.available2019-05-13T09:08:14Z
dc.date.issued2014
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractObjectives: We aimed to evaluate oxidative stress [8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA)] endothelial damage [asymmetric dimethylarginine (ADMA)] and markers of cellular inflammation [interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-?), neopterin (NP) and high-sensitivity C-reactive protein (hsCRP)] in patients with diabetic nephropathy (DN) and non-diabetic nephropathy who were being administered hemodialysis treatment because of chronic renal failure. Methods: In determining 8-OHdG, IL-6 and TNF-? levels, Enzyme-Linked Immuno-Sorbent Assay method was used. Serum MDA, ADMA and NP levels were determined by using high performance liquid chromatography (HPLC). And hs-CRP values were measured with nephelometric method. Results: Serum 8-OHdG and MDA levels were found statistically to have increased when compared with those of the control group in patients groups after dialysis. However, serum ADMA and neopterin levels were observed statistically to have decreased when compared with those of the control group in patients groups after dialysis. But, decreases on ADMA and neopterin levels are still much higher than those of control. IL-6 and TNF-? levels were found to have increased when compared with those of control group in patients groups before dialysis. Conclusion: The oxidative stress in patients with DN, who were being treated with hemodialysis due to chronic renal failure, was higher than that of non-DN patients who were being treated with hemodialysis. In contrast with this, inflammation occurring in non-DN patients was found to have been higher than that of in patients with DN.
dc.identifier.citationAvcı, E., Çakır, E., Coşkun Cevher, S., Yaman, H., Ağıllı, M., Bilgi, C. (2014). Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure. Renal Failure, 36(5), 767-773.
dc.identifier.doi10.3109/0886022X.2014.890841
dc.identifier.endpage773en_US
dc.identifier.issn0886-022X
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage767en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2014.890841
dc.identifier.urihttps://hdl.handle.net/11491/1960
dc.identifier.volume36en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCellular Inflammationen_US
dc.subjectChronic Renal Failureen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectHemodialysisen_US
dc.subjectOxidative Stressen_US
dc.titleDetermination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure
dc.typeArticle

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