Paraoxanase as an indicator of myocardial ischemia and its utility in determining extension of ischemia

dc.contributor.authorErenler, Ali Kemal
dc.contributor.authorKocabaş, Ramazan
dc.contributor.authorDoğan, Tolga
dc.contributor.authorErdemli, Hacı Kemal
dc.contributor.authorYetim, Mücahit
dc.date.accessioned2019-05-13T08:57:43Z
dc.date.available2019-05-13T08:57:43Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground The aim of this study was to investigate Paraoxanase 1 (PON-1) activity in patients with ST-elevated and non-ST-elevated acute myocardial infarction (AMI) and to determine its correlation with Gensini scores (GSs). Methods A total of 109 patients with AMI and 58 healthy subjects as control group were included in the study. Patients were divided into 2 subgroups as ST-elevated and non-ST-elevated AMI patients (Group I and II, respectively). Controls were named as Group III. PON-1 activity was determined on admission to emergency department for each group. In addition, GSs for patient groups were determined. Then, groups were compared according to their results. Results PON-1 levels in Group I and II were significantly lower when compared to Group III. Median GSs for Group I and II were 60 and 64, respectively. The cut-off value of PON-1 for diagnosis of AMI was ? 180 U/L, which was identified by receiver characteristics receiver curve analysis. However, we could not determine a significant relationship between serum PON-1 levels and GSs in patients with AMI. Conclusion PON-1 levels measured on admission to emergency department may be used to rule out AMI. PON-1 levels in AMI patients are found to be inefficient in determining extension of ischemia measured by GS. © 2015 Elsevier Inc. All rights reserved.
dc.identifier.citationErenler, A. K., Kocabaş, R., Doğan, T., Erdemli, H. K., Yetim, M. (2016). Paraoxanase as an indicator of myocardial ischemia and its utility in determining extension of ischemia. The American Journal of Emergency Medicine, 34(1), 45-48.
dc.identifier.doi10.1016/j.ajem.2015.09.008
dc.identifier.endpage48en_US
dc.identifier.issn0735-6757
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2015.09.008
dc.identifier.urihttps://hdl.handle.net/11491/994
dc.identifier.volume34en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW.B. Saunders
dc.relation.ispartofAmerican Journal of Emergency Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleParaoxanase as an indicator of myocardial ischemia and its utility in determining extension of ischemia
dc.typeArticle

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