The value of brain natriuretic peptide in the prosthetic valve thrombosis

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dc.contributor.authorBayram, Zübeyde
dc.contributor.authorGündüz, Sabahattin
dc.contributor.authorGüner, Ahmet
dc.contributor.authorKalçık, Macit
dc.contributor.authorDoğan, Cem
dc.contributor.authorGürsoy, Mustafa Ozan
dc.contributor.authorÖzkan, Mehmet
dc.date.accessioned2021-11-01T15:05:19Z
dc.date.available2021-11-01T15:05:19Z
dc.date.issued2020
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractWe aimed to investigate how prosthetic valve thrombosis (PVT) affects brain natriuretic peptide (BNP) levels and how BNP changes following thrombolytic therapy. The study included 70 consecutive patients with left-sided mechanical PVT who received thrombolytic therapy. The patients were divided into two groups, namely obstructive thrombus (n = 42) and nonobstructive thrombus (NOT, n = 28). BNP levels of patients were assessed before and after thrombolytic therapy. BNP levels were higher in obstructive thrombus group than NOT group in whole study population, in patients with mitral PVT and in patients with aortic PVT [325.0 (189.5-496.0) vs. 84.0 (44.5-140.0), P < 0.001, 323.0 (193-449.0) vs. 59.0 (37.0-131.0), P < 0.001 and 321.0 (132.0-525.0) vs. 99.0 (60.5-173.0), P < 0.001]. BNP levels were positively correlated with transmitral and transaortic mean gradients, and negatively correlated with mitral valve area (r: 0.374, P = 0.013; r: 0.432, P = 0.035 and; r: -0.642, P < 0.001, respectively). BNP values above 165 pg/ml may predict the presence of obstructive thrombus with a sensitivity of 88.0%, and a specificity of 79.0% (AUC = 0.928, 95% confidence interval: 0.871-0.986, P < 0.001). Following thrombolytic therapy, BNP levels (pg/ml) significantly decreased from 325.0 (189.5-496.0) to 137.0 (101.7-224.5), P < 0.001, in all patients with obstructive thrombus, from 323.0 (193.0-449.0) to 129.0 (98.0-223.0), P < 0.001, in patients with only mitral obstructive thrombus and from 321.0 (132.0-525.0) to 181.0 (99.0-217.5), P < 0.001, in patients with only aortic obstructive thrombus. BNP levels are significantly higher in prosthetic valve patients with obstructive thrombus than in those with NOT and decrease in patients with obstructive thrombus after thrombolytic therapy. A cut off value of BNP of at least 165.0 pg/ml was found to discriminate obstructive thrombus from NOT.
dc.identifier.citationBayram, Z., Gündüz, S., Güner, A., Kalçik, M., Dogan, C., Gürsoy, M. O., ... & Özkan, M. (2020). The value of brain natriuretic peptide in the prosthetic valve thrombosis. Blood Coagulation & Fibrinolysis, 31(7), 445-451.
dc.identifier.doi10.1097/MBC.0000000000000943
dc.identifier.endpage451en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue7en_US
dc.identifier.pmid32833803
dc.identifier.scopus2-s2.0-85093705410
dc.identifier.scopusqualityQ3
dc.identifier.startpage445en_US
dc.identifier.urihttps://doi.org/10.1097/MBC.0000000000000943
dc.identifier.urihttps://hdl.handle.net/11491/7221
dc.identifier.volume31en_US
dc.identifier.wosWOS:000588770700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKalçık, Macit
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofBlood Coagulation & Fibrinolysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBrain Natriuretic Peptideen_US
dc.subjectProsthetic Valve Thrombosisen_US
dc.subjectThrombolytic Treatmenten_US
dc.titleThe value of brain natriuretic peptide in the prosthetic valve thrombosis
dc.typeArticle

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