Photocrosslinked methacrylated pectin and methacrylated hyaluronic acıd wound dressing loaded with oleuropein as bioactive agent
dc.contributor.author | Moran Bozer, Büşra | |
dc.contributor.author | Özkahraman, Bengi | |
dc.contributor.author | Mert Balaban, Hümeyra | |
dc.date.accessioned | 2024-02-01T07:04:51Z | |
dc.date.available | 2024-02-01T07:04:51Z | |
dc.date.issued | 2023 | en_US |
dc.department | Rektörlük | |
dc.description.abstract | Oleuropein-loaded photocrosslinked hydrogels, consisting of methacrylated pectin (PEC-MA) andmethacrylated hyaluronic acid (HA-MA), were developed as a new hydrogel wound dressing.Pectin and hyaluronic acid were methacrylated and the composite hydrogels were developed byphotocrosslinking of the methacrylated polymer precursors. Methacrylation and the photocros-slinking reactions were approved by1H-NMR and FTIR analyses. In addition to thermal and mor-phological characterizations, swelling andin vitrodegradation studies were performed. Moreimportantly, bioactivity studies, such as cytotoxicity, genotoxicity and hemolysis were performedto reveal the potential of the oleuropein-loaded photocrosslinked hybrid hydrogels for wounddressing applications.In vitroscratch assay studies showed that oleuropein-loaded wound dressingeffectively promoted the wound healing compared to the control in 24 hrs. Oleuropein-loadedphotocrosslinked hydrogels had no genotoxic and cytotoxic effects on L929 cells and could havea potential for wound healing applications. | |
dc.description.provenance | Submitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-02-01T07:04:41Z No. of bitstreams: 0 | en |
dc.description.provenance | Approved for entry into archive by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-02-01T07:04:51Z (GMT) No. of bitstreams: 0 | en |
dc.description.provenance | Made available in DSpace on 2024-02-01T07:04:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2023 | en |
dc.identifier.citation | Bozer, B. M., Özkahraman, B., & Mert, H. (2023). Photocrosslinked methacrylated pectin and methacrylated hyaluronic acıd wound dressing loaded with oleuropein as bioactive agent. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-13. | |
dc.identifier.doi | 10.1080/00914037.2023.2235875 | |
dc.identifier.issn | 0091-4037 | |
dc.identifier.issn | 1563-535X | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.uri | https://doi.org/10.1080/00914037.2023.2235875 | |
dc.identifier.uri | https://hdl.handle.net/11491/8775 | |
dc.identifier.wos | WOS:001030186300001 | |
dc.identifier.wosquality | Q3 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.institutionauthor | Moran Bozer, Büşra | |
dc.institutionauthor | Özkahraman, Bengi | |
dc.institutionauthor | Mert Balaban, Hümeyra | |
dc.language.iso | en | |
dc.publisher | TAYLOR & FRANCIS AS | |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Hydrogel | en_US |
dc.subject | Wound Dressing | en_US |
dc.subject | Hyaluronic Acid | en_US |
dc.subject | Pectin | en_US |
dc.subject | Oleuropein | en_US |
dc.title | Photocrosslinked methacrylated pectin and methacrylated hyaluronic acıd wound dressing loaded with oleuropein as bioactive agent | |
dc.type | Article |
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