Photocrosslinked methacrylated pectin and methacrylated hyaluronic acıd wound dressing loaded with oleuropein as bioactive agent

Basit Öğe Kaydı
dc.contributor.authorMoran Bozer, Büşra
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorMert Balaban, Hümeyra
dc.date.accessioned2024-02-01T07:04:51Z
dc.date.available2024-02-01T07:04:51Z
dc.date.issued2023en_US
dc.departmentRektörlük
dc.description.abstractOleuropein-loaded photocrosslinked hydrogels, consisting of methacrylated pectin (PEC-MA) andmethacrylated hyaluronic acid (HA-MA), were developed as a new hydrogel wound dressing.Pectin and hyaluronic acid were methacrylated and the composite hydrogels were developed byphotocrosslinking of the methacrylated polymer precursors. Methacrylation and the photocros-slinking reactions were approved by1H-NMR and FTIR analyses. In addition to thermal and mor-phological characterizations, swelling andin vitrodegradation studies were performed. Moreimportantly, bioactivity studies, such as cytotoxicity, genotoxicity and hemolysis were performedto reveal the potential of the oleuropein-loaded photocrosslinked hybrid hydrogels for wounddressing applications.In vitroscratch assay studies showed that oleuropein-loaded wound dressingeffectively promoted the wound healing compared to the control in 24 hrs. Oleuropein-loadedphotocrosslinked hydrogels had no genotoxic and cytotoxic effects on L929 cells and could havea potential for wound healing applications.
dc.description.provenanceSubmitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-02-01T07:04:41Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-02-01T07:04:51Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2024-02-01T07:04:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2023en
dc.identifier.citationBozer, B. M., Özkahraman, B., & Mert, H. (2023). Photocrosslinked methacrylated pectin and methacrylated hyaluronic acıd wound dressing loaded with oleuropein as bioactive agent. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-13.
dc.identifier.doi10.1080/00914037.2023.2235875
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/00914037.2023.2235875
dc.identifier.urihttps://hdl.handle.net/11491/8775
dc.identifier.wosWOS:001030186300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorMoran Bozer, Büşra
dc.institutionauthorÖzkahraman, Bengi
dc.institutionauthorMert Balaban, Hümeyra
dc.language.isoen
dc.publisherTAYLOR & FRANCIS AS
dc.relation.ispartofINTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHydrogelen_US
dc.subjectWound Dressingen_US
dc.subjectHyaluronic Aciden_US
dc.subjectPectinen_US
dc.subjectOleuropeinen_US
dc.titlePhotocrosslinked methacrylated pectin and methacrylated hyaluronic acıd wound dressing loaded with oleuropein as bioactive agent
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu