Preparation and characterization of pH responsive poly(methacrylic acid-acrylamide-N-hydroxyethyl acrylamide) hydrogels for drug delivery systems
[ X ]
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, pH responsive polymers composed of methacrylic acid, acrylamide, and N-hydroxyethyl acrylamide were synthesized by free radical polymerization technique. The characterization was done with Fourier transform infrared spectroscopy and scanning electron microscopy. The swelling and drug release behavior of the hydrogels was determined as a function of time at 37°C in pH 2.1 and 7.4. The swelling and drug release studies showed that increased methacrylic acid amount caused a higher increase in swelling and drug release values at pH 7.4 than those at pH 2.1. In addition, the drug release data were applied to kinetic models such as zero order, first order, and Higuchi equations, and it fit well in the Higuchi model of the hydrogel. © 2015 Wiley Periodicals, Inc.
Açıklama
Anahtar Kelimeler
Adsorption, Copolymers, Drug Delivery Systems, Gels, Kinetics
Kaynak
Journal of Applied Polymer Science
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
133
Sayı
13
Künye
Bal, A., Özkahraman, B., & Özbaş, Z. (2016). Preparation and characterization of p H responsive poly (methacrylic acid?acrylamide?N?hydroxyethyl acrylamide) hydrogels for drug delivery systems. Journal of Applied Polymer Science, 133(13).
