Preparation and characterization of pH responsive poly(methacrylic acid-acrylamide-N-hydroxyethyl acrylamide) hydrogels for drug delivery systems

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dc.authorid0000-0003-1535-4381
dc.contributor.authorBal, Ayça
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorÖzbaş, Zehra
dc.date.accessioned2019-05-10T09:38:55Z
dc.date.available2019-05-10T09:38:55Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Mühendisliği Bölümü
dc.description.abstractIn this study, pH responsive polymers composed of methacrylic acid, acrylamide, and N-hydroxyethyl acrylamide were synthesized by free radical polymerization technique. The characterization was done with Fourier transform infrared spectroscopy and scanning electron microscopy. The swelling and drug release behavior of the hydrogels was determined as a function of time at 37°C in pH 2.1 and 7.4. The swelling and drug release studies showed that increased methacrylic acid amount caused a higher increase in swelling and drug release values at pH 7.4 than those at pH 2.1. In addition, the drug release data were applied to kinetic models such as zero order, first order, and Higuchi equations, and it fit well in the Higuchi model of the hydrogel. © 2015 Wiley Periodicals, Inc.
dc.identifier.citationBal, A., Özkahraman, B., & Özbaş, Z. (2016). Preparation and characterization of p H responsive poly (methacrylic acid?acrylamide?N?hydroxyethyl acrylamide) hydrogels for drug delivery systems. Journal of Applied Polymer Science, 133(13).
dc.identifier.doi10.1002/app.43226
dc.identifier.issn0021-8995
dc.identifier.issue13en_US
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.43226
dc.identifier.urihttps://hdl.handle.net/11491/548
dc.identifier.volume133en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdsorptionen_US
dc.subjectCopolymersen_US
dc.subjectDrug Delivery Systemsen_US
dc.subjectGelsen_US
dc.subjectKineticsen_US
dc.titlePreparation and characterization of pH responsive poly(methacrylic acid-acrylamide-N-hydroxyethyl acrylamide) hydrogels for drug delivery systems
dc.typeArticle

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