Macrophage migration inhibitory factor -173GC variant might increase the risk of behçet's disease

Basit Öğe Kaydı
dc.authorid0000-0001-7639-1122
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorYiğit, Serbülent
dc.contributor.authorTural, Ercan
dc.contributor.authorKalkan, Göknur
dc.contributor.authorTümer, Mehmet Kemal
dc.contributor.authorTekcan, Akın
dc.date.accessioned2019-05-13T08:58:37Z
dc.date.available2019-05-13T08:58:37Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjective: The aim of the present study was to investigate any possible association between the macrophage migration inhibitory factor (MIF) -173GC variant and Behçet's disease (BD) in a group of Turkish patients. Subjects and Methods: A total of 111 patients with BD and 100 healthy controls were enrolled in this study. Genomic DNA was extracted from peripheral lymphocytes. The MIF -173GC variant was genotyped using polymerase chain reaction restriction fragment length polymorphism. The allele and genotype frequencies of patients and controls were compared using the ?2 test. Results: A statistically significant difference in the distribution of the genotype was observed between BD patients and healthy controls. The homo-genotype CC was more prevalent in the patient group compared to the control group (p = 0.008, OR: 0.24, 95% Cl: 0.05-0.78). A significant association was observed when the patients were compared with the controls according to GG + GC versus CC ge-notypes (p = 0.003, OR: 1.21, 95% CI: 0.06-0.063). Allele frequencies of the MIF -173GC variant did not show any statistically significant difference between patients and controls. Conclusion: In this study, we conclude that the CC ge-notype of the MIF -173GC variant may be a risk factor in the pathogenesis of BD in the Turkish population. However, further studies with larger samples are needed to address the exact role of this variant in BD. © 2018 The Author(s) Published by S. Karger AG, Basel.
dc.identifier.doi10.1159/000489340
dc.identifier.endpage289en_US
dc.identifier.issn1011-7571
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage285en_US
dc.identifier.urihttps://doi.org/10.1159/000489340
dc.identifier.urihttps://hdl.handle.net/11491/1170
dc.identifier.volume27en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherS. Karger AG
dc.relation.ispartofMedical Principles and Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectBehçet’s Diseaseen_US
dc.subjectMacrophage Migration Inhibitory Factoren_US
dc.subjectVarianten_US
dc.titleMacrophage migration inhibitory factor -173GC variant might increase the risk of behçet's disease
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
nursalaysefeyda.pdf
Boyut:
530.58 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu