A Controlled Study to Examine the Effect of Topical Sucralfate on Radiofrequency-induced Burn Wounds in Rats

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dc.authoridAytekin, Sema / 0000-0003-1376-1573
dc.authorscopusid16053735000
dc.authorscopusid6603827684
dc.authorscopusid57202494140
dc.authorscopusid16416868600
dc.authorscopusid24171235600
dc.authorscopusid57216406802
dc.authorscopusid6701833049
dc.authorwosidAytekin, Sema / AAS-8763-2021
dc.contributor.authorYaşar, Şirin
dc.contributor.authorYaşar, Bülent
dc.contributor.authorYörüsün, Asli
dc.contributor.authorGüneş, Pembegül
dc.contributor.authorKayadibi, Hüseyin
dc.contributor.authorErçin, Zuhal
dc.contributor.authorAytekin, Sema
dc.date.accessioned2021-11-01T15:05:15Z
dc.date.available2021-11-01T15:05:15Z
dc.date.issued2020
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractSeveral preclinical studies have shown topical sucralfate facilitates wound repair. PURPOSE: This study aimed to evaluate the effect of 10% topical sucralfate on healing radiofrequency-induced burn wounds in rats. METHODS: Twenty (20) male rats were divided into 2 equal groups. Using radiofrequency, 4 full-thickness, 1 cm in diameter round burns were created on the backs of the rats that then were randomized to receive twice-daily treatment for 30 days with 10% sucralfate or neutral cream. Biopsies were taken on days 4, 7, 14, and 21 to analyze fibrin-leukocyte crut, edema density, epidermal-dermal cell infiltration, amount of fibroblast and collagen fibers, amount of elastic fibers, neovascularization-angiogenesis, and reepithelialization-granulation tissue. Data were collected to a spreadsheet and entered into statistical software for analysis. Histopathological features were classified as categorical variables and compared using the.2 test and Fisher's exact test. When chi(2) was used, Yates' correction for continuity was performed. All reported P values were 2-tailed; P less than .05 was considered statistically significant. RESULTS: On day 4, improvement in edema density (P=.034), epidermal detachment (P=.020), epidermal-dermal cell infiltration (P=.007), and polymorphonuclear leukocyte infiltration (P=.021) were statistically more significant in the sucralfate than control group. On day 7, epidermal-dermal cell infiltration (P=.007) and elastic fibers P=.050) were statistically more significant in the sucralfate group. On day 14, angiogenesis (P=.029), reepithelialization (P=.035), and granulation tissue (P=.003) were statistically more significant in the sucralfate group. By the end of the study (day 30), angiogenesis (P=.010), reepithelialization (P<.001), fibroblast density (P=.016), granulation tissue (P=.035), and collagen density (P=.002) were significantly improved in the sucralfate group versus the control group. CONCLUSION: In a rat wound model, 10% topical sucralfate was found to histopathologically facilitate the healing process compared to the control group. Controlled clinical studies are needed to elucidate the effect of this treatment in human wounds.
dc.identifier.citationYaşar, Ş., Yaşar, B., Yörüsün, A., Güneş, P., Kayadibi, H., Ercin, Z., & Aytekin, S. (2020). A Controlled Study to Examine the Effect of Topical Sucralfate on Radiofrequency-induced Burn Wounds in Rats. Wound Management & Prevention, 66(2), 34-42.
dc.identifier.doi10.25270/wmp.2020.2.3442
dc.identifier.endpage42en_US
dc.identifier.issn2640-5237
dc.identifier.issn2640-5245
dc.identifier.issue2en_US
dc.identifier.pmid32294061
dc.identifier.scopus2-s2.0-85116172710
dc.identifier.scopusqualityQ1
dc.identifier.startpage34en_US
dc.identifier.urihttps://doi.org/10.25270/wmp.2020.2.3442
dc.identifier.urihttps://hdl.handle.net/11491/7194
dc.identifier.volume66en_US
dc.identifier.wosWOS:000589347900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKayadibi, Hüseyin
dc.language.isoen
dc.publisherHMP Global
dc.relation.ispartofWound Management & Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPreclinical studyen_US
dc.subjectWound healingen_US
dc.subjectBurnsen_US
dc.subjectSucralfateen_US
dc.subjectTopicalen_US
dc.titleA Controlled Study to Examine the Effect of Topical Sucralfate on Radiofrequency-induced Burn Wounds in Rats
dc.typeArticle

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