eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia

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dc.contributor.authorPehlivan, Sacide
dc.contributor.authorUysal, Mehmet Ali
dc.contributor.authorAydın, Pelin C.
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorYavuzlar, Hazal
dc.contributor.authorKurnaz, Serdar
dc.contributor.authorSever, Ülgen
dc.contributor.authorYavuz, Ferhat K.
dc.contributor.authorUysal, Sezer
dc.contributor.authorAydın, Nazan
dc.date.accessioned2019-05-10T09:38:48Z
dc.date.available2019-05-10T09:38:48Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBACKGROUND: This study aimed to evaluate whether VNTR variants in the Endothelial Nitric Oxide Synthase (eNOS) and the XRCC4 gene play any role in nicotine dependence (ND) and/or Schizophrenia+ND (Sch+ND) ethiopathogenesis. METHODS: Present study included 100 individuals with ND, 60 patients with Sch+ND, and 70 healthy controls. These variants were analyzed using PCR. RESULTS: The cases with ND had higher eNOS VNTR-BB genotype than the healthy control subjects (p = 0.001). eNOS-AA genotype was lower in cases with Sch+ND and ND groups compared to the controls (p = 0.001, p = 0.001, respectively). eNOS-B allele was found significantly more frequently in Sch+ND group compared to the controls (p = 0.001). eNOS-A allele was significantly lower in ND group than the controls (p = 0.001). XRCC4-ID genotype was more common in the ND group than the control group (p = 0.001) as heterozygosity disadvantage. XRCC4-DD genotype was more common in the Sch+ND group compared to the controls (p = 0.035). The frequency of XRCC4-I allele was lower in the Sch+ND group compared to the controls (p = 0.012). CONCLUSIONS: Our results showed that eNOS and XRCC4 VNTR variants might play a potential role in Sch+ND and/or ND pathophysiology.
dc.identifier.citationPehlivan, S., Uysal, M.A., Aydin, P., Pehlivan, M., Nursal, A.F., Yavuzlar, H., Kurnaz, S., Sever, U., Yavuz, F., Uysal, S., & Aydin, N. (2017). eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia. Bratislavske lekarske listy, 118 (8), 467-471 .
dc.identifier.doi10.4149/BLL_2017_090
dc.identifier.endpage471en_US
dc.identifier.issn0006-9248
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage467en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2017_090
dc.identifier.urihttps://hdl.handle.net/11491/486
dc.identifier.volume118en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherComenius University
dc.relation.ispartofBratislava Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndothelial Nitric Oxide Synthaseen_US
dc.subjectNicotine Dependenceen_US
dc.subjectSchizophreniaen_US
dc.subjectXRCC4en_US
dc.titleeNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia
dc.typeArticle

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