Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
De Gruyter
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Morbidly adherent placenta (MAP) is a clinical condition the prevalance of which is steadily increasing. It is described as the invasion of the placenta into the uterine wall through the myometrium and beyond. Several studies have shown that intercellular adhesion molecule-1 (ICAM-1) increases the invasion capability of tumor cells and placental cells. In our study, we investigated the expression of ICAM-1 in MAP cases. This is a prospective case-control study. Eighty-nine patients who were diagnosed with MAP and 96 patients, without adherent placenta, as a control group were included in the study. ICAM-1 staining was examined by immuno-histochemical staining in placental samples. Of the 89 patients in the MAP group, 72 (80.8%) showed positive staining, while 26 (27%) did so in the control group. ICAM-1 positive staining in the MAP group was statistically significantly higher (P=0.03). This is the first study investigating the relationship between MAP and ICAM-1 in the literature. In our study, we showed that ICAM-1 expression increased in the MAP group. © 2019 Walter de Gruyter GmbH, Berlin/Boston.
Açıklama
Anahtar Kelimeler
Adherent Placenta, Adhesion Molecule, ICAM, Invasion, Placental Structure
Kaynak
Journal of Perinatal Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
47
Sayı
1
Künye
Korkmazer, E., Nizam, R., Arslan, E., Akkurt, Ö. (2018). Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta. Journal of Perinatal Medicine, 47(1), 45-49.
