Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta

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dc.contributor.authorKorkmazer, Engin
dc.contributor.authorNizam, Rampia
dc.contributor.authorArslan, Emine
dc.contributor.authorAkkurt, Özgür
dc.date.accessioned2019-05-10T09:40:07Z
dc.date.available2019-05-10T09:40:07Z
dc.date.issued2019
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractMorbidly adherent placenta (MAP) is a clinical condition the prevalance of which is steadily increasing. It is described as the invasion of the placenta into the uterine wall through the myometrium and beyond. Several studies have shown that intercellular adhesion molecule-1 (ICAM-1) increases the invasion capability of tumor cells and placental cells. In our study, we investigated the expression of ICAM-1 in MAP cases. This is a prospective case-control study. Eighty-nine patients who were diagnosed with MAP and 96 patients, without adherent placenta, as a control group were included in the study. ICAM-1 staining was examined by immuno-histochemical staining in placental samples. Of the 89 patients in the MAP group, 72 (80.8%) showed positive staining, while 26 (27%) did so in the control group. ICAM-1 positive staining in the MAP group was statistically significantly higher (P=0.03). This is the first study investigating the relationship between MAP and ICAM-1 in the literature. In our study, we showed that ICAM-1 expression increased in the MAP group. © 2019 Walter de Gruyter GmbH, Berlin/Boston.
dc.identifier.citationKorkmazer, E., Nizam, R., Arslan, E., Akkurt, Ö. (2018). Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta. Journal of Perinatal Medicine, 47(1), 45-49.
dc.identifier.doi10.1515/jpm-2018-0086
dc.identifier.endpage49en_US
dc.identifier.issn0300-5577
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.1515/jpm-2018-0086
dc.identifier.urihttps://hdl.handle.net/11491/846
dc.identifier.volume47en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDe Gruyter
dc.relation.ispartofJournal of Perinatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdherent Placentaen_US
dc.subjectAdhesion Moleculeen_US
dc.subjectICAMen_US
dc.subjectInvasionen_US
dc.subjectPlacental Structureen_US
dc.titleRelationship between intercellular adhesion molecule-1 and morbidly adherent placenta
dc.typeArticle

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