Evaluation of Neuroprotective Effect of Sevoflurane in Acute Traumatic Brain Injury: An Experimental Study in Rats

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dc.contributor.authorDoğan, Güvenç
dc.contributor.authorKaraca, Onur
dc.date.accessioned2021-11-01T18:14:58Z
dc.date.available2021-11-01T18:14:58Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractAIM: To examine the effect of sevoflurane, a halogenated anesthetic used in clinical applications, on oxidative stress and inflammation after an acute traumatic brain injury (TBI) in rats. MATERIAL and METHODS: Thirty male Sprague–Dawley rats were divided into three groups: control (Group 1), trauma (Group 2), and trauma+sevoflurane (Group 3). A diffuse TBI model was created for Groups 2 and 3. Sevoflurane anesthesia was applied 6 hours a day after induced trauma in Group 3. Glutathione (GSH), malondialdehyde (MDA), and tissue myeloperoxidase (MPO) activities were measured in the blood. Tumor necrosis factor alpha (TNF-?), vascular endothelial growth factor (VEGF), and Bax primary antibodies were used to determine the effects of TBI. RESULTS: MDA was significantly higher in Group 2 than in Group 1. There was a significant increase in tissue MPO levels in Groups 2 and 3 compared with those in Group 1. GSH levels decreased in Groups 2 and 3. Group 3 revealed degenerative changes in neurons and glial cells, vascular enlargement and congestion, and inflammatory cell infiltration around blood vessels. In Group 3, VEGF expression was positive in endothelial and inflammatory cells around blood vessels. Group 3 had positive TNF-? expression in neurons, small granular cells, and glial cells around blood vessels. CONCLUSION: Sevoflurane administration in acute TBI did not prevent the development of oxidative stress and inflammation.
dc.identifier.doi10.5137/1019-5149.JTN.27680-19.2
dc.identifier.endpage243en_US
dc.identifier.issn1019-5149
dc.identifier.issue2en_US
dc.identifier.pmid32091120
dc.identifier.scopus2-s2.0-85081945644
dc.identifier.scopusqualityQ3
dc.identifier.startpage237en_US
dc.identifier.urihttps://doi.org10.5137/1019-5149.JTN.27680-19.2
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpVMk5qWXlNZz09
dc.identifier.urihttps://hdl.handle.net/11491/7615
dc.identifier.volume30en_US
dc.identifier.wosWOS:000519545800013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject[No Keywords]en_US
dc.titleEvaluation of Neuroprotective Effect of Sevoflurane in Acute Traumatic Brain Injury: An Experimental Study in Rats
dc.typeArticle

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