The importance of programmed death ligand 1 gene expression, epidermal growth factor receptor gene mutations and serum epidermal growth factor receptor levels in Turkish non-small cell lung cancer patients

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dc.contributor.authorTurna, Akif
dc.contributor.authorHorozoğlu, Cem
dc.contributor.authorKoç Erbaşoğlu, Öncü
dc.contributor.authorErcan, Şeyda
dc.contributor.authorKüçükhüseyin, Özlem
dc.contributor.authorTuran, Saime
dc.contributor.authorHakan, Mehmet Tolgahan
dc.contributor.authorKara, Hasan Volkan
dc.contributor.authorHekimoğlu, Elvin
dc.contributor.authorZeybek, Ümit
dc.contributor.authorCoşkunpınar, Ender
dc.contributor.authorCacına, Canan
dc.contributor.authorErgen, Arzu
dc.contributor.authorYaylım, İlhan
dc.date.accessioned2019-05-13T09:03:10Z
dc.date.available2019-05-13T09:03:10Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractBackground: This study aims to investigate the possible relationships between epidermal growth factor receptor gene mutations, serum epidermal growth factor receptor levels, programmed death ligand gene expression levels and the risks and survivals of resectable nonsmall cell lung cancer patients. Methods: Deoxyribonucleic acid isolation was performed from peripheral blood samples and tumor tissues. The mutation analysis was performed for epidermal growth factor receptor. Programmed death ligand 1 gene expression levels were examined pathologically and histopathologically following the tissue tracing of 36 non-small cell lung cancer patients (29 males, 7 females; mean age 60.1 years; range, 41 to 79 years) and analyzed using real-time polymerase chain reaction. Epidermal growth factor receptor serum levels were assessed in all patients. Results: As a result of mutation analyses in 21 patients (28.5% of all adenocarcinoma patients), epidermal growth factor receptor mutation was determined in at least one exon in six patients. In epidermal growth factor receptor mutation detected patients, programmed death ligand 1 gene expression levels were associated with lymph node metastasis (p=0.036). However, epidermal growth factor receptor mutations were not statistically significantly associated according to histopathological examination (p>0.05). Of patients carrying exon 20 (c.2303G>T) mutations, 25% had tumors with perineural invasion. There was a statistically significant association between exon 20 insertions and c.2303G>T and lymphatic invasion (p=0.02), lymph node metastasis and exon 20 insertions (p=0.03). Patients with lower serum epidermal growth factor receptor levels (<400 pg/mL) had better survival time than those with higher serum epidermal growth factor receptor levels (p=0.04). Conclusion: Programmed death ligand 1 gene expression and epidermal growth factor receptor mutation might have a combined effect on non-small cell lung cancer. Programmed death ligand 1 gene expression in tumor pathology may also be a significant feature for tumor progression and tumorigenesis. Serum epidermal growth factor receptor levels seem to be associated with survival. ©2018 All right reserved by the Turkish Society of Cardiovascular Surgery.
dc.identifier.citationTurna, A., Horozoğlu, C., Koç Erbaşoğlu, Ö., Ercan, Ş., Küçükhüseyin, Ö., Turan, S., Hakan, M. T., Kara, H. V., Elvin, H., Zeybek, Ü., Coşkunpınar, E., Cacına, C., Ergen, A., Yaylım, İ.(2018). The importance of programmed death ligand 1 gene expression, epidermal growth factor receptor gene mutations and serum epidermal growth factor receptor levels in Turkish non-small cell lung cancer patients, The Turkish Journal of Thoracic and Cardiovascular Surgery, 26(3), 450-457.
dc.identifier.doi10.5606/tgkdc.dergisi.2018.15780
dc.identifier.endpage457en_US
dc.identifier.issn1301-5680
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage450en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2018.15780
dc.identifier.urihttps://hdl.handle.net/11491/1418
dc.identifier.volume26en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBayçınar Medical Publishing
dc.relation.ispartofTurkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpidermal Growth Factor Receptoen_US
dc.subjectHistopathology of Tumorsen_US
dc.subjectLung Canceren_US
dc.subjectProgrammed Death Ligand 1en_US
dc.titleThe importance of programmed death ligand 1 gene expression, epidermal growth factor receptor gene mutations and serum epidermal growth factor receptor levels in Turkish non-small cell lung cancer patients
dc.typeArticle

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