The relationship between increased epicardial fat thickness and left ventricular hypertrophy and carotid intima-media thickness in patients with nonfunctional adrenal incidentaloma

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dc.contributor.authorNasıroğlu İmga, Narin
dc.contributor.authorUçar Elalmış, Özgül
dc.contributor.authorTuna, Mazhar Müslüm
dc.contributor.authorAyçiçek Doğan, Berçem
dc.contributor.authorŞahin, Deniz
dc.contributor.authorBerker, Dilek
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-13T09:08:47Z
dc.date.available2019-05-13T09:08:47Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjectives We aimed to evaluate the relationship between EFT and left ventricular hypertrophy and carotid intima-media thickness, which are both strong predictors of cardiovascular morbity and mortality, in patients with nonfunctioning AI. Patients and Methods We evaluated 51 patients (36 females and 15 males) diagnosed with AI and 35 (29 females, 6 males) age, gender and body mass index (BMI) matched healthy controls in terms of cardiovascular risk parameters. Epicardial fat was identified as the echo-free space between the outer wall of the myocardium and the visceral layer of the pericardium. Results Epicardial fat thickness was significantly higher in patients with AI when compared to the control group (0.89 ± 0.32 cm vs. 0.74 ± 0.26 cm; P = 0.023). left ventricular (LV) mass index and median carotid intima-media thickness (CIMT) were also higher in subjects with AI than in controls (99.8 g/m2 vs. 86.9 g/m2; P = 0.024 and 7.5 mm (5.5 - 11.5) vs. 6.5 mm (4.5 - 9.5); P = 0.017). There was a positive correlation between EFT, LV mass index, EFT and CIMT (r = 0.315, P = 0.004; r = 0.363, P < 0.001; respectively). Conclusions In this study we showed that EFT, measured by echocardiography is higher in subjects with AI when compared to healthy controls. epicardial fat thickness had the best independent correlation with AI in multiple logistic regression analysis. Incidentaloma is also associated with increased left ventricular mass index and CIMT. Adrenal incidentaloma patients may show early cardiac changes, such as increased left ventricular mass and increased CIMT.
dc.identifier.citationNasıroğlu İmga, N., Uçar Elalmış, O., Tuna, M. M., Ayçiçek Doğan, B., Şahin, D., Berker, D., Güler, S. (2016). The relationship between increased epicardial fat thickness and left ventricular hypertrophy and carotid intima-media thickness in patients with nonfunctional adrenal incidentaloma. International Journal of Endocrinology and Metabolism, 14(3).
dc.identifier.doi10.5812/ijem.37635
dc.identifier.issn1726-913X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.5812/ijem.37635
dc.identifier.urihttps://hdl.handle.net/11491/2052
dc.identifier.volume14en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKowsar Medical Publishing Company
dc.relation.ispartofInternational Journal of Endocrinology and Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdrenal Incidentalomaen_US
dc.subjectAtherosclerosisen_US
dc.subjectEpicardial Faten_US
dc.titleThe relationship between increased epicardial fat thickness and left ventricular hypertrophy and carotid intima-media thickness in patients with nonfunctional adrenal incidentaloma
dc.typeArticle

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