Stability of complete blood count parameters depends on the storage temperature, storage time, transport position and selected stability criterion

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dc.contributor.authorKayadibi, Hüseyin
dc.contributor.authorAcar, İsmail Aytaç
dc.contributor.authorÇam, Samet
dc.date.accessioned2021-11-01T15:03:04Z
dc.date.available2021-11-01T15:03:04Z
dc.date.issued2020
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractPurpose: To evaluate stability of CBC parameters in samples containing K-3-EDTA in Hema&Tube brand evacuated tubes stored at 4 degrees C and room temperature in upright, horizontal and upside-down transport positions for up to 240 min by comparing with different stability criteria.Methods: A total of 450 outpatient samples, 75 for each condition, were stored for 240 min. Blood samples were analyzed at baseline, 60th, 120th and 240th min of storage time using Sysmex (R) XT-4000i hematology analyzer. CBC results were compared according to the paired samplest-test, one CV% change, CVI, BV DES 2014, RCPA, IQMH, EFLM Biological Variation 2019, ESfEQAand CLIA stability criteria.Results: In all transport conditions, almost all CBC parameters were unstable according to the paired samplest-test. Based on one CV % change RBC, hemoglobin, hematocrit, RDW-CV, neutrophils, platelets, MPV, PDW and plateletcrit were unstable in some transport conditions. However, most parameters were stable at all conditions, except especially for MCH, MPV, PDW and plateletcrit, while just MPV and PDW were unstable at RT in all transport conditions according to the lower and higher CVI, respectively.Conclusions: Paired samplest-test and one CV% change stability criteria are not suitable for decision. Clinical laboratories should establish the impact of storage time, storage temperature and transport positions for each CBC parameter while paying attention to the brand of evacuated tube according to the lower CVI of biological variation data stability criteria since it is more related to the impact of analysis deviation on clinical decisions to prevent misdiagnosis.
dc.identifier.citationKayadibi, H., Acar, I. A., & Cam, S. (2020). Stability of complete blood count parameters depends on the storage temperature, storage time, transport position and selected stability criterion. Scandinavian journal of clinical and laboratory investigation, 80(6), 470-478.
dc.identifier.doi10.1080/00365513.2020.1783570
dc.identifier.endpage478en_US
dc.identifier.issn0036-5513
dc.identifier.issn1502-7686
dc.identifier.issue6en_US
dc.identifier.pmid32597228
dc.identifier.scopus2-s2.0-85087555344
dc.identifier.scopusqualityQ3
dc.identifier.startpage470en_US
dc.identifier.urihttps://doi.org/10.1080/00365513.2020.1783570
dc.identifier.urihttps://hdl.handle.net/11491/6949
dc.identifier.volume80en_US
dc.identifier.wosWOS:000549505000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKayadibi, Hüseyin
dc.institutionauthorAcar, İsmail Aytaç
dc.institutionauthorÇam, Samet
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofScandinavian Journal Of Clinical & Laboratory Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCBCen_US
dc.subjectStability criteriaen_US
dc.subjectStorage temperatureen_US
dc.subjectStorage timeen_US
dc.subjectTransport positionen_US
dc.titleStability of complete blood count parameters depends on the storage temperature, storage time, transport position and selected stability criterion
dc.typeArticle

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