The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status
Yükleniyor...
Dosyalar
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Via Medica
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Granulin (GRN) is an adipokine with proinflammatory features, which plays important role in glucose metabolism and insulin resistance pathogenesis. It has been reported that granulin precursors were localised in developing follides in animal studies. The purpose of this study was to evaluate the association of granulin levels with anthropometric features, glucose metabolism, and ovarian reserve. Material and methods: A total of 109 infertile women were induded in this cross-sectional, prospective study, who attended a tertiary clinic. All participants were categorised into diminished ovarian reserve (DOR) and normal ovarian reserve groups (NOR), in accordance with Bologna criteria. The demographic characteristics, including age, BMI, waist-hip circumferences, and biochemical parameters, were recorded. Serum granulin level was determined by enzyme-linked immunosorbent assay. Results: No significant difference was observed in the GRN levels (p = 0.229) between the groups. There was a positive correlation between GRN levels and BMI, WC, HC, and 75 g oral glucose tolerance values in NOR group (p < 0.01, p < 0.05, p < 0.01, and p < 0.05, respectively). Conclusions: Our results suggest that granulin is associated with anthropometric features in infertile patients and might be an important indicator of obesity and impaired glucose metabolism. Elevated levels of granulin may have a diabetogenic effect and predispose women to high glucose levels.
Açıklama
Anahtar Kelimeler
Granulin, Anthropometry, Glucose Metabolism, Ovarian Reserve, Obesity
Kaynak
Endokrynologia Polska
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
70
Sayı
3
Künye
Kan, O., & Gorkem, U. (2019). The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status. Endokrynologia Polska, 70(3), 255-259.
