The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status

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dc.authoridKan, Özgür / 0000-0003-3994-0094
dc.contributor.authorKan, Özgür
dc.contributor.authorGörkem, Ümit
dc.date.accessioned2021-11-01T15:01:55Z
dc.date.available2021-11-01T15:01:55Z
dc.date.issued2019
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractIntroduction: Granulin (GRN) is an adipokine with proinflammatory features, which plays important role in glucose metabolism and insulin resistance pathogenesis. It has been reported that granulin precursors were localised in developing follides in animal studies. The purpose of this study was to evaluate the association of granulin levels with anthropometric features, glucose metabolism, and ovarian reserve. Material and methods: A total of 109 infertile women were induded in this cross-sectional, prospective study, who attended a tertiary clinic. All participants were categorised into diminished ovarian reserve (DOR) and normal ovarian reserve groups (NOR), in accordance with Bologna criteria. The demographic characteristics, including age, BMI, waist-hip circumferences, and biochemical parameters, were recorded. Serum granulin level was determined by enzyme-linked immunosorbent assay. Results: No significant difference was observed in the GRN levels (p = 0.229) between the groups. There was a positive correlation between GRN levels and BMI, WC, HC, and 75 g oral glucose tolerance values in NOR group (p < 0.01, p < 0.05, p < 0.01, and p < 0.05, respectively). Conclusions: Our results suggest that granulin is associated with anthropometric features in infertile patients and might be an important indicator of obesity and impaired glucose metabolism. Elevated levels of granulin may have a diabetogenic effect and predispose women to high glucose levels.
dc.identifier.citationKan, O., & Gorkem, U. (2019). The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status. Endokrynologia Polska, 70(3), 255-259.
dc.identifier.doi10.5603/EP.a2019.0012
dc.identifier.endpage259en_US
dc.identifier.issn0423-104X
dc.identifier.issue3en_US
dc.identifier.pmid30845343
dc.identifier.scopus2-s2.0-85068570287
dc.identifier.scopusqualityQ3
dc.identifier.startpage255en_US
dc.identifier.urihttps://doi.org/10.5603/EP.a2019.0012
dc.identifier.urihttps://hdl.handle.net/11491/6757
dc.identifier.volume70en_US
dc.identifier.wosWOS:000474881900008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKan, Özgür
dc.institutionauthorGörkem, Ümit
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofEndokrynologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGranulinen_US
dc.subjectAnthropometryen_US
dc.subjectGlucose Metabolismen_US
dc.subjectOvarian Reserveen_US
dc.subjectObesityen_US
dc.titleThe effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status
dc.typeArticle

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