Evaluation of serum CXC chemokine ligand 16 (CXCL16) as a novel inflammatory bio-marker or familial Mediterranean fever disease

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dc.authoridDüzenli, Tolga / 0000-0002-6279-1018
dc.authoridTanoğlu, Alpaslan / 0000-0002-7477-6640
dc.authoridAkyol, Taner / 0000-0001-7495-3216
dc.authorwosidDüzenli, Tolga / R-8685-2019
dc.contributor.authorAkyol, Taner
dc.contributor.authorDüzenli, Tolga
dc.contributor.authorTanoğlu, Alpaslan
dc.date.accessioned2021-11-01T15:05:42Z
dc.date.available2021-11-01T15:05:42Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground/aim: Familial Mediterranean fever (FMF) is a disease that is mainly diagnosed with clinical features. Several wellknown inflammatory markers increase in FMF. However, there is still a need for diagnostic tests for specifying FMF and monitoring inflammatory activity. CXCL16 is a chemokine produced by inflammatory cells that demonstrate efficacy in the acute phase response. In this study, we aimed to investigate the relationship between CXCL16 levels and FMF disease and to evaluate CXCL16 levels as a novel biomarker for FMF. Materials and methods: Fifty-three male patients diagnosed with FMF and sixty healthy individuals were included in this crosssectional study. Blood samples were taken in the first 24 h of the attack periods. Serum soluble CXCL16 was evaluated by enzyme-linked immunosorbent assay (ELISA) method. Results: CXCL16 (P < 0.001), erythrocyte sedimentation rate (P < 0.001), C-reactive protein (P < 0.001), and fibrinogen (P = 0.005) were significantly higher in FMF group than in control group. Receiver operating characteristic (ROC) curve analysis revealed a cut off value of CXCL16 as 2.68 ng/ml with 83% sensitivity and 68% specificity (P < 0.001). Logistic regression analysis indicated that high CXCL16 and erythrocyte sedimentation rate levels were predictive parameters for FMF disease (OR 8.31; 95% CI 2.59-26.62; p <0.001) (OR 1.27; 95% CI 1.12-1.44; P < 0.001). There was no correlation between CXCL16 levels and attack frequency and disease duration (P = 0.395, P = 0.956). Conclusion: To the best of our knowledge, this is the first study evaluating serum soluble CXCL16 levels as a biomarker for FMF. CXCL16 levels were significantly higher and were predictive for monitoring inflammatory activity in patients with FMF. CXCL16 may be a promising biomarker for FMF diagnosis.
dc.identifier.citationAkyol, T., Düzenli, T., & Tanoğlu, A. (2021). Evaluation of serum CXC chemokine ligand 16 (CXCL16) as a novel inflammatory biomarker or familial Mediterranean fever disease. Turkish Journal of Medical Sciences, 51(2), 813-818.
dc.identifier.doi10.3906/sag-2010-64
dc.identifier.endpage818en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid33306334
dc.identifier.scopus2-s2.0-85105473073
dc.identifier.scopusqualityQ1
dc.identifier.startpage813en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2010-64
dc.identifier.urihttps://hdl.handle.net/11491/7376
dc.identifier.volume51en_US
dc.identifier.wosWOS:000646231300002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDüzenli, Tolga
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFamilial mediterranean feveren_US
dc.subjectCXCL 16en_US
dc.subjectInflammationen_US
dc.subjectSerum CXC Chemokine Ligand 16en_US
dc.subjectBiomarkeren_US
dc.titleEvaluation of serum CXC chemokine ligand 16 (CXCL16) as a novel inflammatory bio-marker or familial Mediterranean fever disease
dc.typeArticle

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