Lipoic Acid Decreases 3-Nitrotyrosine and Cytokine Levels In A Rat Sepsis Model
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Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
It was aimed to investigate the effects of lipoic acid (LA) on 3-nitrotyrosine (3-NT), interleukin-1? (IL-1?), tumor necrosis factor- ? (TNF-?), magnesium and trace elements levels in serum of rats with sepsis. Control group (n=10) received a single dose of saline, lipopolysaccharide (LPS) group ( n=10) was injected a single dose of 20 mg/kg LPS, and LA+LPS (n=10) group was injected a single dose of 20 mg/kg LPS at the end of third day of 10 mg/kg/day LA injection. The serum 3-NT levels were determined by a high performance liquid chromatography. The serum levels of IL-1? and TNF-? were measured by enzyme linked immunosorbent assay. Determination of magnesium and trace element levels were performed by inductively coupled plasma mass spectromet er. 3-NT, IL-1? and TNF-? levels in control and LA+LPS groups were not determined. However, observable levels of these parameters were detected in the LPS group. It was found that manganese levels were positively correlated with IL-1? and TNF-? in LPS group. LA increased the manganese levels, while it decreased magnesium and iron levels in LA+LPS group. Our results show that LA decreases serum levels of 3-NT, IL-1? and TNF-? in rats with sepsis, and it is also effective on trace element levels. Decreased levels of manganese and its association with IL-1? and TNF-? in the LPS group suggest that manganese may be associated with immune response.
Açıklama
Anahtar Kelimeler
Diş Hekimliği, Farmakoloji ve Eczacılık, Toksikoloji
Kaynak
Eastern Journal of Medicine
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
24
Sayı
3
