Lipoic Acid Decreases 3-Nitrotyrosine and Cytokine Levels In A Rat Sepsis Model

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dc.contributor.authorÇimen, Behzat
dc.contributor.authorÇimen, Leyla
dc.contributor.authorÇetin, İhsan
dc.date.accessioned2021-11-01T18:14:53Z
dc.date.available2021-11-01T18:14:53Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractIt was aimed to investigate the effects of lipoic acid (LA) on 3-nitrotyrosine (3-NT), interleukin-1? (IL-1?), tumor necrosis factor- ? (TNF-?), magnesium and trace elements levels in serum of rats with sepsis. Control group (n=10) received a single dose of saline, lipopolysaccharide (LPS) group ( n=10) was injected a single dose of 20 mg/kg LPS, and LA+LPS (n=10) group was injected a single dose of 20 mg/kg LPS at the end of third day of 10 mg/kg/day LA injection. The serum 3-NT levels were determined by a high performance liquid chromatography. The serum levels of IL-1? and TNF-? were measured by enzyme linked immunosorbent assay. Determination of magnesium and trace element levels were performed by inductively coupled plasma mass spectromet er. 3-NT, IL-1? and TNF-? levels in control and LA+LPS groups were not determined. However, observable levels of these parameters were detected in the LPS group. It was found that manganese levels were positively correlated with IL-1? and TNF-? in LPS group. LA increased the manganese levels, while it decreased magnesium and iron levels in LA+LPS group. Our results show that LA decreases serum levels of 3-NT, IL-1? and TNF-? in rats with sepsis, and it is also effective on trace element levels. Decreased levels of manganese and its association with IL-1? and TNF-? in the LPS group suggest that manganese may be associated with immune response.
dc.identifier.doi10.5505/ejm.2019.14237
dc.identifier.endpage270en_US
dc.identifier.issn1301-0883
dc.identifier.issn1339-3886
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85071254770
dc.identifier.scopusqualityQ4
dc.identifier.startpage265en_US
dc.identifier.urihttps://doi.org10.5505/ejm.2019.14237
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpJMk5UZzRPQT09
dc.identifier.urihttps://hdl.handle.net/11491/7551
dc.identifier.volume24en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiş Hekimliğien_US
dc.subjectFarmakoloji ve Eczacılıken_US
dc.subjectToksikolojien_US
dc.titleLipoic Acid Decreases 3-Nitrotyrosine and Cytokine Levels In A Rat Sepsis Model
dc.typeArticle

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