In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes
| dc.authorid | 0000-0002-4778-2981 | |
| dc.contributor.author | Koncuk Cebeci, Büşra | |
| dc.contributor.author | Alım, Zuhal | |
| dc.contributor.author | Beydemir, Şükrü | |
| dc.date.accessioned | 2019-03-28T06:18:26Z | |
| dc.date.available | 2019-03-28T06:18:26Z | |
| dc.date.issued | 2014 | |
| dc.department | Hitit Üniversitesi, Alaca Avni Çelik Meslek Yüksekokulu, Gıda İşleme Bölümü | |
| dc.description.abstract | The organophosphate target enzyme paraoxonase-1 (PON1) has been extensively studied in toxicology. Pesticides are organophosphate compounds that are commonly used in agriculture. They are also used as nerve gases, such as sarin and soman. Therefore, the effects of these compounds on enzymatic activity are well known. In the present study, we investigated the in vitro effects of fenoxaprop-p-ethyl, lambda cyhalothrin, imidacloprid, and dichlorvos pesticides on sheep liver microsomal PON1. The enzyme was purified approximately 141-fold with a specific activity of 1822.22 EU/mg proteins. The pesticides inhibited sheep liver PON1 in vitro, and the IC_ {50} values for these compounds were 0.0103, 0.069, 0.157, and 0.2\mu M, respectively. | |
| dc.description.provenance | Submitted by Büşra CEBECİ (busrakoncuk@hitit.edu.tr) on 2019-03-25T08:53:10Z No. of bitstreams: 1 PON1.pdf: 1131058 bytes, checksum: cef0ab63d1079b68d31b7fd33cbc492b (MD5) | en |
| dc.description.provenance | Approved for entry into archive by Fatma Özdemir (fatmaozdemir@hitit.edu.tr) on 2019-03-28T06:18:26Z (GMT) No. of bitstreams: 1 PON1.pdf: 1131058 bytes, checksum: cef0ab63d1079b68d31b7fd33cbc492b (MD5) | en |
| dc.description.provenance | Made available in DSpace on 2019-03-28T06:18:26Z (GMT). No. of bitstreams: 1 PON1.pdf: 1131058 bytes, checksum: cef0ab63d1079b68d31b7fd33cbc492b (MD5) Previous issue date: 2014-05-12 | en |
| dc.identifier.citation | Koncuk Cebeci, B., Alım, Z., Beydemir Ş. (2014). In vitro effects of pesticide exposure on the activity of the paraoxonase 1 enzyme from sheep liver microsomes. Turkish Journal of Chemistry, 38, 512-520. | |
| dc.identifier.doi | 10.3906/kim-1308-20 | |
| dc.identifier.endpage | 520 | en_US |
| dc.identifier.issn | 1300-0527 | |
| dc.identifier.issn | 1303-6130 | |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 512 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11491/310 | |
| dc.identifier.uri | https://doi.org/10.3906/kim-1308-20 | |
| dc.identifier.volume | 38 | en_US |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | |
| dc.publisher | The Scientific and Technological Research Council of Turkey (TÜBİTAK) | |
| dc.relation.ispartof | Turkish Journal of Chemistry | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Paraoxonase | en_US |
| dc.subject | Fenoxaprop-p-ethyl | en_US |
| dc.subject | Lambda Cyhalothrin | en_US |
| dc.subject | Imidacloprid | en_US |
| dc.subject | Dichlorvos | en_US |
| dc.subject | Inhibition | en_US |
| dc.title | In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes | |
| dc.type | Article |
