The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy

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dc.contributor.authorMuratoğlu Şahin, Nursel
dc.contributor.authorPeltek Kendirci, Havva Nur
dc.contributor.authorÇetinkaya, Semra
dc.contributor.authorSavaş Erdeve, Şenay
dc.contributor.authorAycan, Zehra
dc.date.accessioned2020-01-31T10:09:22Z
dc.date.available2020-01-31T10:09:22Z
dc.date.issued2020en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: Some studies have examined the effect of gonadal suppression on insulin-like growth factor-1 (IGF-1) levels and the growth velocity (GV) with conflicting results.Methods: Forty-four girls treated with gonadotropin-releasing hormone analogue (GnRHa) for central precocious puberty (CPP) were included in the study. IGF-1 levels were examined at the beginning and after 12 months of treatment.Results: IGF-1 and IGF-1 standard deviation score (SUS) according to chronological age (CA-IGF-1 SUS) at diagnosis were positively correlated with chronological age (CA), anthropometric measurements, stage of puberty, bone age (BA), BA-CA, follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, uterus length, endometrium thickness and ovarian volume (OV) at diagnosis (p <0.05). There was no significant difference in IGF-1 levels after treatment. However, there was a negative correlation between Delta IGF-1 SDS and IGF-1 level, CA-IGF-1 SDS and BA-IGF-1 SDS at diagnosis (p <0.05). There was no correlation between GV and IGF-1, Delta IGF-1. GV was negatively correlated with basal LH level at diagnosis (p = 0.008, r=-0.397). Peak LH levels of the patients who had GV-SDS <0 were more suppressive than those of the patients who had GV-SDS> 0 after 12 months of treatment. Conclusions: It was determined that the IGF-1 level and CA-IGF-1 SDS at baseline were correlated with more advanced pubertal stage prior to treatment. Initiation of treatment with a relatively high level of IGF-1 increased the risk of a decrease in the IGF-1 level. Likewise, the initiation of treatment with a relatively high LH level may increase the risk of low GV, but low GV was not related to the IGF-1 level. Increased sex steroid suppression may increase the risk of low GV.
dc.description.provenanceSubmitted by Zeynep Umut Arslan (umutarslan@hitit.edu.tr) on 2020-01-31T10:09:01Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Zeynep Umut Arslan (umutarslan@hitit.edu.tr) on 2020-01-31T10:09:22Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-01-31T10:09:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.citationMuratoglu Sahin, N., Peltek Kendirci, H. N., Çetinkaya, S., Savas Erdeve, S., Aycan, Z. (2020). The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy. Journal of pediatric endocrinology & metabolism : JPEM, 33(1): 113-120.
dc.identifier.doi10.1515/jpem-2018-0482
dc.identifier.endpage120en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2018-0482
dc.identifier.urihttps://hdl.handle.net/11491/5674
dc.identifier.volume33en_US
dc.identifier.wosWOS:000506671100013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofJournal of pediatric endocrinology & metabolism : JPEM
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGnRHa Treatmenten_US
dc.subjectGrowth Velocityen_US
dc.subjectIGF-1en_US
dc.subjectPrecocious Pubertyen_US
dc.titleThe alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy
dc.typeArticle

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