Investigation of toxic effects of mushroom poisoning on the cardiovascular system

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dc.contributor.authorErenler, Ali Kemal
dc.contributor.authorDoğan, Tolga
dc.contributor.authorKoçak, Cem
dc.contributor.authorEce, Yasemin
dc.date.accessioned2019-05-13T09:07:04Z
dc.date.available2019-05-13T09:07:04Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractMushroom poisoning (MP) is a public health problem in many countries. It is well known that consumption of wild mushrooms may cause serious toxicity on renal, hepatic and brain functions. In the literature, however, studies investigating cardiotoxic effects of MP are rare. In this study, we evaluated laboratory and ECG findings of patients and sought for possible toxic effects of MP on the cardiovascular system. During a 2-year period, 175 patients with MP were included in the study. The majority of the poisonings occurred in early summertime. The most common complaint was found to be nausea and vomiting followed by mental status alterations. Methods of treatment were mainly based on gastric lavage, activated charcoal and supportive therapy. The most common ECG abnormalities in the patients with MP were sinus tachycardia, sinus arrhythmia, ST/T inversion, 1st degree AV block and QT prolongation, respectively. Cardiac markers of the patients were found to be normal. Then, patients were divided into two subgroups according to symptom onset after consumption (less than 6 hr and more than 6 hr). When the two groups were compared, prevalence of tachycardia was significantly higher in Group II. Additionally, the interval between mushroom consumption and onset of symptoms was strongly correlated with blood pressure (BP). As this interval prolonged, BP of the patients tended to increase. In conclusion, according to our results, although mechanisms need to be clarified, MP causes hypertension and ECG alterations, particularly tachycardia in patients with late-onset symptoms. © 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)
dc.identifier.citationErenler, A. K., Doğan, T., Koçak, C., Ece, Y. (2016). Investigation of toxic effects of mushroom poisoning on the cardiovascular system. Basic and Clinical Pharmacology and Toxicology, 119(3), 317-321.
dc.identifier.doi10.1111/bcpt.12569
dc.identifier.endpage321en_US
dc.identifier.issn1742-7835
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.1111/bcpt.12569
dc.identifier.urihttps://hdl.handle.net/11491/1714
dc.identifier.volume119en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.relation.ispartofBasic and Clinical Pharmacology and Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleInvestigation of toxic effects of mushroom poisoning on the cardiovascular system
dc.typeArticle

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