Should insulin resistance be screened in lean hirsute women?
[ X ]
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Informa Healthcare
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The role of insulin resistance (IR) is well-documented in obese women with polycystic ovary syndrome (PCOS). Controversies exist concerning the presence of IR in idiopathic hirsutism (IH) or if it is a manifestation of high body mass index (BMI). We aimed to investigate the presence/absence of IR in lean hirsute women. One-hundred fifty-one lean women with hirsutism [96 PCOS (group 1) and 55 IH (group 2)] and 58 age-and BMI-matched healthy controls (group 3) were recruited in the study (mean age 25.21±6.1 versus 26.26±4.6years; BMI 21.79±1.7 versus 22.02±2.2kg/m, respectively). Significantly higher insulin and HOMA-IR, and significantly lower fasting glucose insulin ratio (FGIR), quantitative insulin sensitivity check index (QUICKI), reciprocal insulin, and Raynaud index were detected in groups 1 and 2 than in group 3 (p<0.05). These IR indices were similar between groups 1 and 2. The number of patients with IR (HOMA-IR>2, FGIR<7.2, or QUICKI<0.357) was significantly higher in groups 1 and 2 than in group 3, but was similar between groups 1 and 2. A higher frequency of IR occurs in lean hirsute women regardless of they having PCOS or IH. IR may contribute to aetiopathogenesis of IH, or may cause some metabolic abnormalities in these patients
Açıklama
Anahtar Kelimeler
Idiopathic Hirsutism, Insulin Resistance, Lean Women, Polycystic Ovary Syndrome
Kaynak
Gynecological Endocrinology
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
31
Sayı
4
Künye
Arduç, A., Sarıçam, O., Ayçiçek Doğan, B., Tuna, M. M., Ateş Tütütncü, Y., Işık, S., Berker, D., Şennaroğlu, E.[et.al.]. (2015). Should insulin resistance be screened in lean hirsute women?. Gynecological Endocrinology, 31(4), 291-295.
