Should insulin resistance be screened in lean hirsute women?

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dc.contributor.authorArduç, Ayşe
dc.contributor.authorSarıçam, Orkun
dc.contributor.authorAyçiçek Doğan, Berçem
dc.contributor.authorTuna, Mazhar Müslüm
dc.contributor.authorAteş Tütüncü, Yasemin
dc.contributor.authorIşık, Serhat
dc.contributor.authorBerker, Dilek
dc.contributor.authorŞennaroğlu, Engin
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-13T08:58:18Z
dc.date.available2019-05-13T08:58:18Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractThe role of insulin resistance (IR) is well-documented in obese women with polycystic ovary syndrome (PCOS). Controversies exist concerning the presence of IR in idiopathic hirsutism (IH) or if it is a manifestation of high body mass index (BMI). We aimed to investigate the presence/absence of IR in lean hirsute women. One-hundred fifty-one lean women with hirsutism [96 PCOS (group 1) and 55 IH (group 2)] and 58 age-and BMI-matched healthy controls (group 3) were recruited in the study (mean age 25.21±6.1 versus 26.26±4.6years; BMI 21.79±1.7 versus 22.02±2.2kg/m, respectively). Significantly higher insulin and HOMA-IR, and significantly lower fasting glucose insulin ratio (FGIR), quantitative insulin sensitivity check index (QUICKI), reciprocal insulin, and Raynaud index were detected in groups 1 and 2 than in group 3 (p<0.05). These IR indices were similar between groups 1 and 2. The number of patients with IR (HOMA-IR>2, FGIR<7.2, or QUICKI<0.357) was significantly higher in groups 1 and 2 than in group 3, but was similar between groups 1 and 2. A higher frequency of IR occurs in lean hirsute women regardless of they having PCOS or IH. IR may contribute to aetiopathogenesis of IH, or may cause some metabolic abnormalities in these patients
dc.identifier.citationArduç, A., Sarıçam, O., Ayçiçek Doğan, B., Tuna, M. M., Ateş Tütütncü, Y., Işık, S., Berker, D., Şennaroğlu, E.[et.al.]. (2015). Should insulin resistance be screened in lean hirsute women?. Gynecological Endocrinology, 31(4), 291-295.
dc.identifier.doi10.3109/09513590.2014.994598
dc.identifier.endpage295en_US
dc.identifier.issn0951-3590
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage291en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2014.994598
dc.identifier.urihttps://hdl.handle.net/11491/1110
dc.identifier.volume31en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIdiopathic Hirsutismen_US
dc.subjectInsulin Resistanceen_US
dc.subjectLean Womenen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.titleShould insulin resistance be screened in lean hirsute women?
dc.typeArticle

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