Evaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotic release

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dc.authoridKılıç Süloğlu, Aysun / 0000-0003-0914-1128
dc.authoridTamahkar, Emel / 0000-0002-5913-8333
dc.authoridPerçin, Işık / 0000-0002-9453-4462
dc.authorwosidKılıç Süloğlu, Aysun / AAG-4181-2019
dc.authorwosidPerçin, Işık / G-9159-2013
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorTamahkar, Emel
dc.contributor.authorİdil, Neslihan
dc.contributor.authorKılıç Süloğlu, Aysun
dc.contributor.authorPerçin, Işık
dc.date.accessioned2021-11-01T15:05:48Z
dc.date.available2021-11-01T15:05:48Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Malzeme Mühendisliği Bölümü
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractThe development of chitosan-gelatin (CS-G) hydrogels embedded with ampicillin-loaded hyaluronic acid nanoparticles (HA-NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA-NPs into biocompatible CS-G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS-G/HA-NPs hydrogels after 5 days. Antibacterial performance of CS-G/HA-NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS-G/HA-NPs hydrogels compared with CS-G group after 24 hr incubation. Consequently, the potential ability of CS-G/HA-NPs hydrogels as a controlled drug delivery system has been verified.
dc.description.sponsorshipHitit University Scientific and Technical Application and Research Centeren_US
dc.description.sponsorshipThe authors are grateful to the support of Hitit University Scientific and Technical Application and Research Center.en_US
dc.identifier.citationÖzkahraman, B., Tamahkar, E., İdil, N., Kılıç Suloglu, A., & Perçin, I. (2021). Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release. Drug Development Research, 82(2), 241-250.
dc.identifier.doi10.1002/ddr.21747
dc.identifier.endpage250en_US
dc.identifier.issn0272-4391
dc.identifier.issn1098-2299
dc.identifier.issue2en_US
dc.identifier.pmid33009868
dc.identifier.scopus2-s2.0-85091851085
dc.identifier.scopusqualityQ2
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1002/ddr.21747
dc.identifier.urihttps://hdl.handle.net/11491/7407
dc.identifier.volume82en_US
dc.identifier.wosWOS:000574568700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkahraman, Bengi
dc.institutionauthorTamahkar, Emel
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofDrug Development Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntibiotic Releaseen_US
dc.subjectChitosan-gelatin Hydrogelsen_US
dc.subjectHyaluronic Acid Nanoparticles Embeddingen_US
dc.titleEvaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotic release
dc.typeArticle

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