Thiol-disulfide homeostasis in children with celiac disease

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dc.authoridgureser, Ayse semra / 0000-0002-6455-5932
dc.authoridTaylan-Ozkan, Aysegul / 0000-0001-8421-3625
dc.authoridComba, Atakan / 0000-0002-8576-9550
dc.authoridEREL, Ozcan / 0000-0002-2996-3236
dc.authoridSENAT, Almila / 0000-0002-5806-562X
dc.authorwosidgureser, Ayse semra / E-9513-2018
dc.authorwosidTaylan-Ozkan, Aysegul / B-9721-2016
dc.contributor.authorComba, Atakan
dc.contributor.authorGüreser, Ayşe Semra
dc.contributor.authorKarasartova, Djursun
dc.contributor.authorSenat, Almila
dc.contributor.authorErel, Özcan
dc.contributor.authorTaylan Özkan, Hikmet Ayşegül
dc.date.accessioned2021-11-01T15:05:04Z
dc.date.available2021-11-01T15:05:04Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractBackground Toxic gliadin peptide damages enterocytes in celiac disease by causing oxidative stress. Thiols are organic compounds that defend against oxidative stress. This study aimed to investigate the changes in thiol-disulfide homeostasis in children with celiac disease. Methods The study included patients with celiac disease, children diagnosed with functional gastrointestinal disorders, and healthy children. Patients' serum native and total thiol-disulfide amounts, disulfide/total thiol percentage ratios, disulfide / native thiol percentage ratios, and native thiol/total thiol percentage ratios were measured. Results The study involved 172 children, of whom 90 (52.3%) were girls. The mean participant age was 8.6 +/- 4.2 years. A total of 59 (34.3%) children had celiac disease, 56 (32.6%) had functional gastrointestinal disorders, and 57 (33.1%) were healthy. The total thiol and disulfide levels of patients with celiac disease (305 +/- 87 mu mol/L and 25 +/- 15 mu mol/L, respectively) were significantly lower than those of healthy children (349 +/- 82 mu mol/L and 40 +/- 15 mu mol/L, respectively) (P= 0.006 andP <0.001, respectively). Native and total thiol levels (226 +/- 85 mu mol/L and 279 +/- 99 mu mol/L, respectively) in patients with celiac disease who consumed a gluten-containing diet were significantly lower than those of patients who consumed a gluten-free diet (278 +/- 64 mu mol/L and 327 +/- 69 mu mol/L, respectively) (P= 0.017 andP= 0.041, respectively). Conclusions Thiol-disulfide homeostasis, an important antioxidant defense component of the gastrointestinal system, is disrupted in children with celiac disease. A gluten-free diet helped partially ameliorate this decline.
dc.identifier.doi10.1111/ped.14243
dc.identifier.endpage956en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue8en_US
dc.identifier.pmid32239752
dc.identifier.scopus2-s2.0-85083454140
dc.identifier.scopusqualityQ3
dc.identifier.startpage950en_US
dc.identifier.urihttps://doi.org/10.1111/ped.14243
dc.identifier.urihttps://hdl.handle.net/11491/7092
dc.identifier.volume62en_US
dc.identifier.wosWOS:000562804600010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKarasartova, Djursun
dc.institutionauthorGüreser, Ayşe Semra
dc.institutionauthorTaylan Özkan, Hikmet Ayşegül
dc.institutionauthorComba, Atakan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPediatrics International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectceliac diseaseen_US
dc.subjectchilden_US
dc.subjectdisulfideen_US
dc.subjectoxidative stressen_US
dc.subjectthiolen_US
dc.titleThiol-disulfide homeostasis in children with celiac disease
dc.typeArticle

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