The IL-1Ra gene variable number tandem repeat variant is associated with susceptibility to temporomandibular disorders in Turkish population

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dc.authorid0000-0001-7639-1122
dc.contributor.authorTümer, Mehmet Kemal
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorTekcan, Akın
dc.contributor.authorYerliyurt, Kaan
dc.contributor.authorGeyko, Anastasia
dc.contributor.authorYiğit, Serbülent
dc.date.accessioned2019-05-13T08:57:54Z
dc.date.available2019-05-13T08:57:54Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: Temporomandibular joint disorders (TMD) are a group of disorders involving temporomandibular joint and related structures. Interleukine-1 receptor antagonist (IL-1Ra) is an important anti-inflammatory molecule that competes with other interleukin-1 molecules. This study was designed to investigate the possible association of the IL-1Ra VNTR variant with the risk of TMD in the Turkish population. Methods: Peripheral blood samples were collected from 100 patients with TMD (23 males, 77 females) and 110 healthy individuals (35 males, 75 females). Genotyping of IL-1Ra 86 bp VNTR variant was evaluated by gel electrophoresis after polymerase chain reaction (PCR). Results: Our results show that there is a statistically significant difference between TMD patients and control group with respect to IL-1Ra genotype distribution and allele frequencies. 1.2, 1.4, and 4.4 genotypes were more common in patients, while 2.2 and 3.3 genotypes were rarer (P<.000). Frequency of alleles 1 and 4 was higher in patient groups (P<.000), whereas alleles 2 and 3 had a lower frequency in patients with TMD (P<.000). Conclusions: This is the first correlation study that evaluates the association between IL-1Ra gene VNTR variant and TMD. The VNTR variant related to IL-1Ra gene showed a strong pattern of association with TMD that may have a potential impact on disease counseling and management. Larger studies with various ethnicities are needed to establish the impact of IL-1Ra VNTR variant on risk of developing TMD. © 2017 Wiley Periodicals, Inc.
dc.identifier.citationTümer, M. K., Nursal, A. F., Tekcan, A., Yerliyurt, K., Geyko, A., Yiğit, S. (2018). The IL?1Ra gene variable number tandem repeat variant is associated with susceptibility to temporomandibular disorders in Turkish population. Journal of Clinical Laboratory Analysis, 32(2), e22255.
dc.identifier.doi10.1002/jcla.22255
dc.identifier.issn0887-8013
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/jcla.22255
dc.identifier.urihttps://hdl.handle.net/11491/1030
dc.identifier.volume32en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInterleukine-1 Receptor Antagonisten_US
dc.subjectTemporomandibular Joint Disordersen_US
dc.subjectVNTR Varianten_US
dc.titleThe IL-1Ra gene variable number tandem repeat variant is associated with susceptibility to temporomandibular disorders in Turkish population
dc.typeArticle

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