Clinical implication of totally occluded infarct-related coronary artery in non-ST-segment elevation myocardial infarction: the TOTAL-NSTEMI study

Basit Öğe Kaydı
dc.contributor.authorGüner, Ahmet
dc.contributor.authorÇörekçioğlu, Büşra
dc.contributor.authorUzun, Fatih
dc.contributor.authorKalçık, Macit
dc.contributor.authorUlutaş, Ahmet Emir
dc.date.accessioned2024-01-25T11:18:10Z
dc.date.available2024-01-25T11:18:10Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackgroundA subset ofpatients found to have total occlusion of the culprit artery (TOCA), present with non-ST-segment elevation myocardial infarction (NSTEMI) and elevated biomarkers. The aim of this study is to assess the effect of the TOCA in patients presenting with NSTEMI. MethodsThis multicenter observational study was retrospectively conducted between 2015 and 2019. Thrombolysis in myocardial infarction (TIMI) flow grades 0-1 was defined as the TOCA. The primary end point included a combination of all-cause death, myocardial infarction, target vessel revascularization, stent thrombosis, and stroke. ResultsOf 3272 patients, TIMI 0-1 flow in the culprit artery was present in 488 (14.9%) patients. TOCA was more likely to be of thrombotic origin (54.1% vs. 10.3%; P < 0.001) and visible collaterals (22.5% vs. 4.4%; P < 0.001). The rates of 30-day (14.3% vs. 7.2%; P < 0.001) and 2-year (25% vs. 19.1%; P = 0.003) primary end points were significantly higher in TOCA patients. Fatal arrhythmias were remarkably higher at 30-day (8.6% vs. 4%; P < 0.001) and 2-year (9% vs. 5.2%; P = 0.001) follow-ups. Mechanical complications were also higher in patients with TOCA at 30 days (0.8% vs. 0.2%; P = 0.013). Moreover, TOCA (OR, 1.379; P = 0.001) was one of the independent predictors of MACCE in NSTEMI patients. ConclusionThe current data suggest that patients with TOCA in the context of NSTEMI are at higher risk of MACCE, fatal arrhythmias, and mechanical complications.
dc.description.provenanceSubmitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-01-25T11:17:57Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-01-25T11:18:10Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2024-01-25T11:18:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2023en
dc.identifier.citationGüner, A., Çörekçioğlu, B., Uzun, F., Kalcik, M., Ulutaş, A. E., Akman, C., ... & Ertürk, M. (2023). Clinical implication of totally occluded infarct-related coronary artery in non-ST-segment elevation myocardial infarction: the TOTAL-NSTEMI study. Coronary Artery Disease, 34(2), 127-133.
dc.identifier.doi10.1097/MCA.0000000000001212
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.pmid36720021
dc.identifier.scopusqualityQ3
dc.identifier.urihttp://journals.lww.com/coronary-artery
dc.identifier.urihttps://hdl.handle.net/11491/8741
dc.identifier.wosWOS:000924066800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKalçık, Macit
dc.language.isoen
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofCoronary Artery Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFatal arrhythmiasen_US
dc.subjectMajor cardiovascular and cerebral eventsen_US
dc.subjectMechanical complicationsen_US
dc.subjectMyocardial infarctionen_US
dc.subjectTotal occlusionen_US
dc.titleClinical implication of totally occluded infarct-related coronary artery in non-ST-segment elevation myocardial infarction: the TOTAL-NSTEMI study
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu