Skin-homing T-cell responses associated with Demodex infestation and rosacea

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dc.authoridgureser, Ayse semra / 0000-0002-6455-5932
dc.authoridMumcuoglu, Kosta / 0000-0001-8125-6099
dc.authoridDerici, Mehmet Kursat / 0000-0002-8260-7492
dc.authoridTaylan-Ozkan, Aysegul / 0000-0001-8421-3625
dc.authorwosidgureser, Ayse semra / E-9513-2018
dc.authorwosidMumcuoglu, Kosta / AAY-2122-2020
dc.authorwosidDerici, Mehmet Kursat / AAE-2031-2019
dc.authorwosidTaylan-Ozkan, Aysegul / B-9721-2016
dc.contributor.authorGazi, Umut
dc.contributor.authorGüreser, Ayşe Semra
dc.contributor.authorÖztekin, Aynure
dc.contributor.authorKarasartova, Djursun
dc.contributor.authorKoşar Acar, Nezahat
dc.contributor.authorDerici, Mehmet Kürşat
dc.contributor.authorTaylan Özkan, Hikmet Ayşegül
dc.date.accessioned2021-11-01T15:02:58Z
dc.date.available2021-11-01T15:02:58Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractAims Our aim was to investigate the skin-homing T-cell immune responses triggered in patients with Demodex infestation and/or rosacea. Methods Collected whole blood samples were divided into four groups: control subjects; nonrosacea patients with Demodex infestation (Demodex group); papulopustular rosacea (PPR) patients without Demodex infestation (Rosacea group); and PPR patients with Demodex infestation (Rosacea/Demodex group). Following ex vivo activation, skin-homing CLA+CD4+ T-cell subset levels were monitored by flow cytometry. Results When compared with control subjects, among skin-homing CD4+ T-cell subsets analysed, Demodex patients had higher T(H)9 and T-reg cell levels; Rosacea subjects displayed elevated T(H)1 cell levels; and Rosacea/Demodex patients exhibited increased frequencies of T(H)9 and T(H)22 cells. In contrast to Rosacea subjects, Rosacea/Demodex group members displayed higher T(H)2 cell levels; and when compared with Demodex groups, they had higher T(H)1 and T(H)2 but lower T-reg cell levels. Demodex group members also exhibited higher T-reg but lower T(H)1 and T(H)22 levels than Rosacea/Demodex group subjects. Conclusions The skin-homing T-cell responses associated with Demodex infestation and rosacea formation seem to influence each other. The present as well as future studies could contribute to the development of effective treatment strategies for demodicosis and rosacea.
dc.description.sponsorshipHitit University Scientific Research Projects UnitHitit University [TIP19002.16.005]en_US
dc.description.sponsorshipHitit University Scientific Research Projects Unit, Grant/Award Number: TIP19002.16.005en_US
dc.identifier.doi10.1111/pim.12658
dc.identifier.issn0141-9838
dc.identifier.issn1365-3024
dc.identifier.issue8en_US
dc.identifier.pmid31125450
dc.identifier.scopus2-s2.0-85067468017
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/pim.12658
dc.identifier.urihttps://hdl.handle.net/11491/6890
dc.identifier.volume41en_US
dc.identifier.wosWOS:000475958100003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüreser, Ayşe Semra
dc.institutionauthorÖztekin, Aynure
dc.institutionauthorKarasartova, Djursun
dc.institutionauthorTaylan Özkan, Hikmet Ayşegül
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofParasite Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCD4+en_US
dc.subjectCLAen_US
dc.subjectDemodexen_US
dc.subjectrosaceaen_US
dc.subjectT cellsen_US
dc.titleSkin-homing T-cell responses associated with Demodex infestation and rosacea
dc.typeArticle

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