Evaluation of ovarian reserve in women with overt or subclinical hypothyroidism

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dc.contributor.authorKüçükler, Ferit Kerim
dc.contributor.authorGörkem, Ümit
dc.contributor.authorŞimşek, Yasin
dc.contributor.authorKocabaş, Ramazan
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-13T09:07:01Z
dc.date.available2019-05-13T09:07:01Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractIntroduction: Thyroid dysfunction is among the most common autoimmune disorders in women of reproductive age. Previous studies have shown the association between autoimmune thyroid disease (AITD) and infertility. Anti-Müllerian hormone (AMH) is secreted by granulosa cells and is a useful marker for assessment of ovarian reserve. In the present study, we sought to evaluate the ovarian reserves of women with autoimmune thyroid disorder by measurement of AMH values. Material and methods: This prospective study included women with newly diagnosed AITD aged between 20 and 40 years. Patients were divided into three groups: Subclinical hypothyroidism (SCH, n = 21), overt hypothyroidism (OH, n = 21) and controls (CG, n = 32). Study parameters included serum free T4, free T3, thyroid-stimulating hormone, anti-thyroglobulin, anti-thyroid peroxidase antibodies, follicle-stimulating hormone, luteinizing hormone, estradiol and AMH concentrations measured in the early follicular phase. Antral follicle count (AFC) was assessed with ultrasound. Body mass index (BMI) and waist circumference of the patients were noted. Results: No significant difference was found among SCH, OH and CG in regard to ovarian reserves measured by AMH values (p = 0.19) and AFC (p = 0.80). A significant negative correlation was found between AMH and BMI (r = -0.382, p = 0.001). Anti-Müllerian hormone and waist circumference (r = -0.330, p = 0.004) were also negatively correlated. Conclusions: Although AMH values were not significantly different among groups, AMH values were lower in OH and SCH patients, indicating a possible need for close monitoring of these patients. © 2016 Termedia & Banach.
dc.identifier.citationKüçükler, F. K., Görkem, Ü., Şimşek, Y., Kocabaş, R., Güler, S. (2018). Evaluation of ovarian reserve in women with overt or subclinical hypothyroidism. Archives of Medical Science: AMS, 14(3), 521-526.
dc.identifier.doi10.5114/aoms.2016.58621
dc.identifier.endpage526en_US
dc.identifier.issn1734-1922
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage521en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2016.58621
dc.identifier.urihttps://hdl.handle.net/11491/1705
dc.identifier.volume14en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd.
dc.relation.ispartofArchives of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-Müllerian Hormoneen_US
dc.subjectAutoimmune Thyroid Diseaseen_US
dc.subjectFertile Womenen_US
dc.titleEvaluation of ovarian reserve in women with overt or subclinical hypothyroidism
dc.typeArticle

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