A novel multilayer hydrogel wound dressing for antibiotic release
[ X ]
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the novel multilayer (ML) hydrogels were developed as antibacterial wound dressings. ML hydrogels were prepared as four layers using carboxylated polyvinyl alcohol (PVA-C), gelatin (G), hyaluronic acid (HA) and gelatin respectively. The upper layers (PVA-C and G) provide the moist control and physical barrier for microorganisms. The HA based middle layer was designed as an antibiotic-loaded layer. The lower layer serves as the controlling membrane for antibiotic release and provides the removal of excess exudate from the wound site. The ML hydrogels were characterized with FT-IR, SEM, DSC, swelling tests and hydrolytic degradation tests. Cell viability assay was also performed in L929 fibroblast cells in vitro. The in-vitro drug release profile of ML hydrogels was investigated at pH 7.4 at 37 degrees C and it was found that 63% of the antibiotic was released after 7 days.
Açıklama
Anahtar Kelimeler
Multilayer Hydrogels, Wound Dressing, Antibiotic Release, Antibacterial Activity
Kaynak
Journal Of Drug Delivery Science And Technology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
58
Sayı
Künye
Tamahkar, E., Özkahraman, B., Süloğlu, A. K., İdil, N., & Perçin, I. (2020). A novel multilayer hydrogel wound dressing for antibiotic release. Journal of Drug Delivery Science and Technology, 58, 101536.
