A novel multilayer hydrogel wound dressing for antibiotic release

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dc.authoridKılıç Süloğlu, Aysun / 0000-0003-0914-1128
dc.authoridPerçin, Işık / 0000-0002-9453-4462
dc.authoridTamahkar, Emel / 0000-0002-5913-8333
dc.authoridÖzkahraman, Bengi / 0000-0003-1535-4381
dc.authorwosidPerçin, Işık / G-9159-2013
dc.authorwosidKılıç Süloğlu, Aysun / AAG-4181-2019
dc.contributor.authorTamahkar, Emel
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorKılıç Süloğlu, Aysun
dc.contributor.authorİdil, Neslihan
dc.contributor.authorPerçin, Işık
dc.date.accessioned2021-11-01T15:05:05Z
dc.date.available2021-11-01T15:05:05Z
dc.date.issued2020
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Malzeme Mühendisliği Bölümü
dc.description.abstractIn this study, the novel multilayer (ML) hydrogels were developed as antibacterial wound dressings. ML hydrogels were prepared as four layers using carboxylated polyvinyl alcohol (PVA-C), gelatin (G), hyaluronic acid (HA) and gelatin respectively. The upper layers (PVA-C and G) provide the moist control and physical barrier for microorganisms. The HA based middle layer was designed as an antibiotic-loaded layer. The lower layer serves as the controlling membrane for antibiotic release and provides the removal of excess exudate from the wound site. The ML hydrogels were characterized with FT-IR, SEM, DSC, swelling tests and hydrolytic degradation tests. Cell viability assay was also performed in L929 fibroblast cells in vitro. The in-vitro drug release profile of ML hydrogels was investigated at pH 7.4 at 37 degrees C and it was found that 63% of the antibiotic was released after 7 days.
dc.identifier.citationTamahkar, E., Özkahraman, B., Süloğlu, A. K., İdil, N., & Perçin, I. (2020). A novel multilayer hydrogel wound dressing for antibiotic release. Journal of Drug Delivery Science and Technology, 58, 101536.
dc.identifier.doi10.1016/j.jddst.2020.101536
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85084400792
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2020.101536
dc.identifier.urihttps://hdl.handle.net/11491/7099
dc.identifier.volume58en_US
dc.identifier.wosWOS:000551583700003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTamahkar, Emel
dc.institutionauthorÖzkahraman, Bengi
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal Of Drug Delivery Science And Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMultilayer Hydrogelsen_US
dc.subjectWound Dressingen_US
dc.subjectAntibiotic Releaseen_US
dc.subjectAntibacterial Activityen_US
dc.titleA novel multilayer hydrogel wound dressing for antibiotic release
dc.typeArticle

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