XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Universidade de Sao Paulo
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Oxidative stress induced DNA damage has been assumed to contribute to the etiopathogenesis of schizophrenia (Sch). Smoking prevalence was more common in patients with Sch. The X-ray repair cross-complementation group 4 (XRCC4) gene plays an important role in the repair of DNA double-strand breaks. Objective: The purpose of this study was to investigate whether XRCC4 rs6869366 polymorphism has a relationship both in nicotine dependence (ND) and Sch+ND risk. Methods: One hundred and four patients with Sch+ND, 133 subjects with ND only and 70 healthy controls were enrolled in the study. XRCC4 rs6869366 polymorphism was analyzed using PCR-RFLP assay. Results: The frequency of XRCC4 rs6869366 GG genotype was more common in the ND and Sch+ND group than controls (p = 0.001 and p = 0.001, respectively). XRCC4 rs6869366 TT genotype was lower in both ND and Sch+ND group compared to controls (p = 0.001 and p = 0.001, respectively). Also, XRCC4 rs6869366 G allele was higher in Sch+ND group than controls (p = 0.001) while XRCC4 rs6869366 T allele was lower in ND group than healthy controls (p=0.001). XRCC4 rs6869366 GT genotype was lower in ND group than control group (p = 0.003). Discussion: These results suggested that the XRCC4 rs6869366 polymorphism G related genotype/allele was associated with susceptibility to both ND and Sch+ND in a Turkish population. © 2018, Universidade de Sao Paulo. All rights reserved.
Açıklama
Anahtar Kelimeler
DNA Repair, Nicotine Dependence, Schizophrenia, XRCC4
Kaynak
Archives of Clinical Psychiatry
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
45
Sayı
3
Künye
Pehlivan, S., Uysal, M. A., Aydın, N., Nursal, A. F., Pehlivan, M., Yavuzlar, H., Sever, Ü., Yavuz, F. K., Uysal, S., Çetinay Aydın, P. (2018). XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia. Archives of Clinical Psychiatry, 45(3), 53-56.
