XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia

Basit Öğe Kaydı
dc.authorid0000-0001-7639-1122
dc.contributor.authorPehlivan, Sacide
dc.contributor.authorUysal, Metin Atilla
dc.contributor.authorAydın, Nazan
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorYavuzlar, Hazal
dc.contributor.authorSever, Ülgen
dc.contributor.authorKurnaz, Selin
dc.contributor.authorYavuz, Fatih Kasım
dc.contributor.authorUysal, Suna
dc.contributor.authorÇetinay Aydın, Pınar
dc.date.accessioned2019-05-10T09:39:25Z
dc.date.available2019-05-10T09:39:25Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: Oxidative stress induced DNA damage has been assumed to contribute to the etiopathogenesis of schizophrenia (Sch). Smoking prevalence was more common in patients with Sch. The X-ray repair cross-complementation group 4 (XRCC4) gene plays an important role in the repair of DNA double-strand breaks. Objective: The purpose of this study was to investigate whether XRCC4 rs6869366 polymorphism has a relationship both in nicotine dependence (ND) and Sch+ND risk. Methods: One hundred and four patients with Sch+ND, 133 subjects with ND only and 70 healthy controls were enrolled in the study. XRCC4 rs6869366 polymorphism was analyzed using PCR-RFLP assay. Results: The frequency of XRCC4 rs6869366 GG genotype was more common in the ND and Sch+ND group than controls (p = 0.001 and p = 0.001, respectively). XRCC4 rs6869366 TT genotype was lower in both ND and Sch+ND group compared to controls (p = 0.001 and p = 0.001, respectively). Also, XRCC4 rs6869366 G allele was higher in Sch+ND group than controls (p = 0.001) while XRCC4 rs6869366 T allele was lower in ND group than healthy controls (p=0.001). XRCC4 rs6869366 GT genotype was lower in ND group than control group (p = 0.003). Discussion: These results suggested that the XRCC4 rs6869366 polymorphism G related genotype/allele was associated with susceptibility to both ND and Sch+ND in a Turkish population. © 2018, Universidade de Sao Paulo. All rights reserved.
dc.identifier.citationPehlivan, S., Uysal, M. A., Aydın, N., Nursal, A. F., Pehlivan, M., Yavuzlar, H., Sever, Ü., Yavuz, F. K., Uysal, S., Çetinay Aydın, P. (2018). XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia. Archives of Clinical Psychiatry, 45(3), 53-56.
dc.identifier.doi10.1590/0101-60830000000157
dc.identifier.endpage56en_US
dc.identifier.issn0101-6083
dc.identifier.issn1806-938X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.1590/0101-60830000000157
dc.identifier.urihttps://hdl.handle.net/11491/690
dc.identifier.volume45en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversidade de Sao Paulo
dc.relation.ispartofArchives of Clinical Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/legalcode*
dc.subjectDNA Repairen_US
dc.subjectNicotine Dependenceen_US
dc.subjectSchizophreniaen_US
dc.subjectXRCC4en_US
dc.titleXRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
0101-6083-rpc-45-03-0053.pdf
Boyut:
158.8 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu