Prognostic importance of bone marrow uptake on baseline 18F-FDG positron emission tomography in diffuse large B cell lymphoma

Basit Öğe Kaydı
dc.authorid0000-0003-0241-5878
dc.contributor.authorSoydal, Çi?dem
dc.contributor.authorKöksoy, Elif Berna
dc.contributor.authorYaşar, Arzu
dc.contributor.authorTurgal, Ebru
dc.contributor.authorDo?anay Erdoğan, Beyza
dc.contributor.authorAkbulut, Hakan
dc.contributor.authorKüçük, Nuriye Özlem
dc.date.accessioned2019-05-13T09:02:29Z
dc.date.available2019-05-13T09:02:29Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractAim: To define the role of 18F-flourodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in the detection of bone marrow (BM) involvement in patients with diffuse large B cell lymphoma (DLBCL). Materials and Methods: Fifty-four (mean age: 55.5 ± 18.3 years, 20 female and 34 male) DLBCL patients who underwent pretreatment 18F-FDG PET/CT were included to the study. Focal or diffuse BM 18F-FDG uptake that is higher than mediastinal blood pool uptake was accepted as positive. After staging of disease by CT and 18F-FDG PET/CT, all the patients received R-CHOP treatment after diagnostic blinded bone marrow biopsy (BMB). Presence of positive BM uptake in 18F-FDG PET/CT and histopathological examination results of BMBs were analyzed by Chi-square test. Sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of 18F-FDG PET/CT in the detection of BM involvement were calculated. Prognostic importance of the presence of BM 18F-FDG uptake was analyzed by Kaplan-Meier analysis. Results: BM 18F-FDG uptake was detected in 8 patients. Histopathological examination of BMB revealed BM involvement in 6 out of 8 patients. BMB was negative in all patients who have no 18F-FDG uptake in the evaluation of PET/CT images. Sensitivity, specificity, accuracy, PPV, and NPV of 18F-FDG PET/CT in the detection of BM involvement were calculated as 100%, 96%, 96%, 75%, and 100%, respectively. In the Kaplan-Meier analysis, we found that presence of pretreatment 18F-FDG uptake in BM has a prognostic importance. Whereas mean time to progression (TTP) in patients with BM uptake was 32.25 ± 10.9 months and mean TTP in those without was 51.69 ± 3.6 months (p = 0.013). Conclusions: BM uptake in pretreatment 18F-FDG PET/CT is an important prognostic factor in DLBCL patients. Moreover, in consideration of high NPV, 18F-FDG PET/CT could eliminate unnecessary BMB in FDG-negative patients. © 2016, Mary Ann Liebert, Inc. 2016.
dc.identifier.citationSoydal, C., Köksoy, E. B., Yaşar, A., Turgal, E., Erdoğan, B. D., Akbulut, H., Küçük, N. Ö. (2016). prognostic importance of bone marrow uptake on baseline 18F-FDG positron emission tomography in diffuse large B cell lymphoma. Cancer Biotherapy and Radiopharmaceuticals, 31(10), 361-365.
dc.identifier.doi10.1089/cbr.2016.2132
dc.identifier.endpage365en_US
dc.identifier.issn1084-9785
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage361en_US
dc.identifier.urihttps://doi.org/10.1089/cbr.2016.2132
dc.identifier.urihttps://hdl.handle.net/11491/1262
dc.identifier.volume31en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert Inc.
dc.relation.ispartofCancer Biotherapy and Radiopharmaceuticals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject18F-FDG Positron Emission Tomography/ Computed Tomographyen_US
dc.subjectBone Marrow Involvementen_US
dc.subjectDiffuse Large B Cell Lymphomaen_US
dc.titlePrognostic importance of bone marrow uptake on baseline 18F-FDG positron emission tomography in diffuse large B cell lymphoma
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu