Leishmaniasis in Northern Cyprus: Human cases and their association with risk factors

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dc.authorid0000-0001-8421-3625
dc.contributor.authorRuh, Emrah
dc.contributor.authorBostancı, Ayşegül
dc.contributor.authorKunter, Vasfiye
dc.contributor.authorTosun, Özgür
dc.contributor.authorImir, Turgut
dc.contributor.authorSchallig, Henk
dc.contributor.authorTaylan Özkan, Hikmet Ayşegül
dc.date.accessioned2019-05-13T08:58:34Z
dc.date.available2019-05-13T08:58:34Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground & objectives: Cyprus is located in the eastern part of the Mediterranean Region where leishmaniasis is endemic. The primary objective of this study was to investigate human visceral leishmaniasis (VL) in the northern region of Cyprus where presence of canine leishmaniasis (CanL) and sandflies has been documented in earlier studies. The secondary objective was to assess the association of leishmaniasis with demographic and epidemiological variables. Methods: Intravenous blood samples were collected from 249 volunteers in Kyrenia district (located in the northern coastal region of Cyprus). Whole blood samples were tested for DNA of Leishmania spp by polymerase chain reaction (PCR), while serum samples were analyzed using direct agglutination test (DAT) and rK39 test. For evaluation of possible risk factors, a questionnaire was applied to the participants. Results: Only three (1.2%) of 249 participants were found seropositive by DAT (n = 2) or rK39 test (n = 1). The remaining samples were negative in serology, and no PCR positivity was detected in any of the 249 participants. Seven individuals, including the seropositive cases, had a history of cutaneous leishmaniasis (CL). Seropositivity and CL were not significantly related with gender (M/F: 40.2/59.8%), age [Mean: 42.85 ± 17.45, Median: 40 (7–86)], occupation (Indoor/Outdoor: 84.7/12.9%), dog ownership (52.6%), and CanL history (5.3%). However, a statistical association was found between seropositivity and past CL infection. Also, a significant relation was observed between participants living in peripheral area (63.1%) and CL infection. Furthermore, leishmaniasis awareness (28.1%) among the study population was statistically correlated with past CL infection and dog ownership. Interpretation & conclusion: This study demonstrates the presence of leishmaniasis and highlight the need for implementation of efficient control measures on the northern coast of Cyprus. © 2017, Malaria Research Center. All rights reserved.
dc.identifier.citationRuh, E., Bostancı, A., Kunter, V., Tosun, O., Imir, T., Schallig, H.,Taylan Özkan, A. (2017). Leishmaniasis in northern Cyprus: Human cases and their association with risk factors. Journal of Vector Borne Diseases, 54(4), 358-365.
dc.identifier.doi10.4103/0972-9062.225842
dc.identifier.endpage365en_US
dc.identifier.issn0972-9062
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage358en_US
dc.identifier.urihttps://doi.org/10.4103/0972-9062.225842
dc.identifier.urihttps://hdl.handle.net/11491/1160
dc.identifier.volume54en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMalaria Research Center
dc.relation.ispartofJournal of Vector Borne Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiagnosisen_US
dc.subjectEpidemiologyen_US
dc.subjectLeishmaniasisen_US
dc.subjectNorthern Cyprusen_US
dc.subjectRisk Factorsen_US
dc.titleLeishmaniasis in Northern Cyprus: Human cases and their association with risk factors
dc.typeArticle

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