Hitit Index to distinguish patients with and without Crimean-Congo hemorrhagic fever

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dc.authoridUlusu, Nuray N. / 0000-0002-3173-1389
dc.authoridYapar, Derya / 0000-0003-3566-9751
dc.authoridAkdoğan, Özlem / 0000-0003-2969-474X
dc.authorwosidUlusu, Nuray N. / AAF-1827-2019
dc.authorwosidYapar, Derya / F-1583-2015
dc.authorwosidErtan, Aslı / AAE-6201-2021
dc.contributor.authorKayadibi, Hüseyin
dc.contributor.authorYapar, Derya
dc.contributor.authorAkdoğan, Özlem
dc.contributor.authorUlusu, Nuray N.
dc.contributor.authorBaykam, Nurcan
dc.date.accessioned2021-11-01T15:02:02Z
dc.date.available2021-11-01T15:02:02Z
dc.date.issued2019
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractCrimean-Congo hemorrhagic fever (CCHF) is fatal. Therefore, it is very important to use an inexpensive, easily accessible, quick and accurate screening index based on clinical signs and laboratory parameters to identify patients suspected of having CCHF. Laboratory test results on the day of hospitalization for 268 inpatients suspected of having CCHF were used to calculate the laboratory section of the Hitit Index, while 65 of these were also monitored daily during their hospital stay to develop the clinical section of the Hitit Index. Two-hundred CCHF-negative outpatients were also evaluated. One-hundred and forty-nine inpatients were CCHF-positive and 119 inpatients were CCHF-negative. The Hitit Index is 5.6 - (5.3*lymphocyte) - (0.02*fibrinogen) - (12*direct bilirubin) + (0.04*AST) + (0.32*hematocrit) - (0.5*neutrophil) - (0.07*CKD-EPI) - (0.001*CK) +/- conjunctival hyperemia (+1.5 in conjunctival hyperemia presence and -1.5 in conjunctival hyperemia absence). In 65 inpatients monitored daily, Hitit Index results for CCHF-positive and negative inpatients were 6.10(1.90-12.30) and -5.35(-8.83- -1.95), while CCHF-negative outpatients were -10.99(-15.64- -6.95) (P < 0.001), respectively. On hospitalization day, just one inpatient was false-negative in 27 CCHF-positive inpatients, while four were false-positive among 38 CCHF-negative inpatients using the Hitit Index. After 24 h, just one inpatient was diagnosed falsely among 27 CCHF-positive and 38 CCHF-negative inpatients, and there was no change after 48 h. Management of patients living in endemic regions suspected of having CCHF could be achieved within minutes using the Hitit Index. Patients with Hitit Index less than zero can be monitored as outpatients, while patients with Hitit Index results above zero must be hospitalized in infectious diseases wards. This study was not registered since it was retrospective.
dc.identifier.citationKayadibi, H., Yapar, D., Akdogan, O., Ulusu, N. N., & Baykam, N. (2019). Hitit Index to distinguish patients with and without Crimean-Congo hemorrhagic fever. Ticks and tick-borne diseases, 10(5), 1035-1040.
dc.identifier.doi10.1016/j.ttbdis.2019.05.010
dc.identifier.endpage1040en_US
dc.identifier.issn1877-959X
dc.identifier.issn1877-9603
dc.identifier.issue5en_US
dc.identifier.pmid31160263
dc.identifier.scopus2-s2.0-85066333204
dc.identifier.scopusqualityQ1
dc.identifier.startpage1035en_US
dc.identifier.urihttps://doi.org/10.1016/j.ttbdis.2019.05.010
dc.identifier.urihttps://hdl.handle.net/11491/6817
dc.identifier.volume10en_US
dc.identifier.wosWOS:000476551500012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKayadibi, Hüseyin
dc.institutionauthorYapar, Derya
dc.institutionauthorAkdoğan, Özlem
dc.institutionauthorBaykam, Nurcan
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofTicks And Tick-Borne Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCrimean-Congo hemorrhagic feveren_US
dc.subjectEarly diagnosisen_US
dc.subjectHitit Indexen_US
dc.titleHitit Index to distinguish patients with and without Crimean-Congo hemorrhagic fever
dc.typeArticle

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